FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018692561> ?p ?o ?g. }

• W2018692561 endingPage "1162" @default.
• W2018692561 startingPage "1157" @default.
• W2018692561 abstract "<b>Background:</b> BCL-2 and BAX are important in the regulation of apoptosis. There have been reports of loss of BCL-2 in basal cells of oral epithelial dysplasia (OED) and in oral squamous cell carcinoma (OSCC), and suppression of BAX in poorly differentiated OSCC. <b>Aim:</b> To investigate whether loss of BCL-2 in OED and OSCC, and of BAX in poorly differentiated OSCC could be attributed to <i>BCL-2</i> and <i>BAX</i> mutations. <b>Methods:</b> Immunohistochemistry and in situ hybridisation were used to confirm BCL-2 and BAX expression. DNA was extracted from archival samples of OED (n = 22) and OSCC (n = 28). The connective tissue part from each section was collected separately and used as the normal reference. <b>Results:</b> No mutations were detected in <i>BCL-2</i> or <i>BAX</i> that could explain their aberrant expression at the mRNA and protein levels in OED and OSCC. The reported A/G polymorphism at codon 7 of <i>BCL-2</i> was detected in 18 of 50 samples and a novel C/T polymorphism at codon 100 was detected in three of 50 samples. <b>Conclusions:</b> No mutations were found that could explain loss of BCL-2 in oral dysplasia and carcinoma. An unreported C/T polymorphism in <i>BCL-2</i> was detected. Downregulation of BCL-2 in OED and OSCC may be the result of transcriptional regulation." @default.
• W2018692561 created "2016-06-24" @default.
• W2018692561 creator A5033578996 @default.
• W2018692561 creator A5081858014 @default.
• W2018692561 creator A5085662310 @default.
• W2018692561 date "2005-11-01" @default.
• W2018692561 modified "2023-10-18" @default.
• W2018692561 title "Loss of BCL-2 in the progression of oral cancer is not attributable to mutations" @default.
• W2018692561 cites W1501414399 @default.
• W2018692561 cites W1510932698 @default.
• W2018692561 cites W1527354001 @default.
• W2018692561 cites W1654947539 @default.
• W2018692561 cites W1975964287 @default.
• W2018692561 cites W1979152565 @default.
• W2018692561 cites W1979778216 @default.
• W2018692561 cites W1979995768 @default.
• W2018692561 cites W1985706752 @default.
• W2018692561 cites W1988839887 @default.
• W2018692561 cites W2012265204 @default.
• W2018692561 cites W2017993044 @default.
• W2018692561 cites W2019598680 @default.
• W2018692561 cites W2033847504 @default.
• W2018692561 cites W2034125993 @default.
• W2018692561 cites W2036402320 @default.
• W2018692561 cites W2046339703 @default.
• W2018692561 cites W2046839020 @default.
• W2018692561 cites W2053462331 @default.
• W2018692561 cites W2058591356 @default.
• W2018692561 cites W2067927788 @default.
• W2018692561 cites W2076020247 @default.
• W2018692561 cites W2087464670 @default.
• W2018692561 cites W2092759765 @default.
• W2018692561 cites W2093873750 @default.
• W2018692561 cites W2094799975 @default.
• W2018692561 cites W2112591674 @default.
• W2018692561 cites W2118792227 @default.
• W2018692561 cites W2119683782 @default.
• W2018692561 cites W2134230584 @default.
• W2018692561 cites W2142189637 @default.
• W2018692561 cites W2142599810 @default.
• W2018692561 cites W2323598111 @default.
• W2018692561 cites W2415638941 @default.
• W2018692561 cites W2416598154 @default.
• W2018692561 doi "https://doi.org/10.1136/jcp.2004.021709" @default.
• W2018692561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1770776" @default.
• W2018692561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16254104" @default.
• W2018692561 hasPublicationYear "2005" @default.
• W2018692561 type Work @default.
• W2018692561 sameAs 2018692561 @default.
• W2018692561 citedByCount "22" @default.
• W2018692561 countsByYear W20186925612012 @default.
• W2018692561 countsByYear W20186925612013 @default.
• W2018692561 countsByYear W20186925612015 @default.
• W2018692561 countsByYear W20186925612016 @default.
• W2018692561 countsByYear W20186925612017 @default.
• W2018692561 countsByYear W20186925612018 @default.
• W2018692561 countsByYear W20186925612019 @default.
• W2018692561 countsByYear W20186925612021 @default.
• W2018692561 countsByYear W20186925612022 @default.
• W2018692561 countsByYear W20186925612023 @default.
• W2018692561 crossrefType "journal-article" @default.
• W2018692561 hasAuthorship W2018692561A5033578996 @default.
• W2018692561 hasAuthorship W2018692561A5081858014 @default.
• W2018692561 hasAuthorship W2018692561A5085662310 @default.
• W2018692561 hasBestOaLocation W20186925611 @default.
• W2018692561 hasConcept C142724271 @default.
• W2018692561 hasConcept C153911025 @default.
• W2018692561 hasConcept C190283241 @default.
• W2018692561 hasConcept C203014093 @default.
• W2018692561 hasConcept C204232928 @default.
• W2018692561 hasConcept C2775894508 @default.
• W2018692561 hasConcept C2777546739 @default.
• W2018692561 hasConcept C2781340805 @default.
• W2018692561 hasConcept C3019992690 @default.
• W2018692561 hasConcept C502942594 @default.
• W2018692561 hasConcept C54355233 @default.
• W2018692561 hasConcept C71924100 @default.
• W2018692561 hasConcept C86803240 @default.
• W2018692561 hasConceptScore W2018692561C142724271 @default.
• W2018692561 hasConceptScore W2018692561C153911025 @default.
• W2018692561 hasConceptScore W2018692561C190283241 @default.
• W2018692561 hasConceptScore W2018692561C203014093 @default.
• W2018692561 hasConceptScore W2018692561C204232928 @default.
• W2018692561 hasConceptScore W2018692561C2775894508 @default.
• W2018692561 hasConceptScore W2018692561C2777546739 @default.
• W2018692561 hasConceptScore W2018692561C2781340805 @default.
• W2018692561 hasConceptScore W2018692561C3019992690 @default.
• W2018692561 hasConceptScore W2018692561C502942594 @default.
• W2018692561 hasConceptScore W2018692561C54355233 @default.
• W2018692561 hasConceptScore W2018692561C71924100 @default.
• W2018692561 hasConceptScore W2018692561C86803240 @default.
• W2018692561 hasIssue "11" @default.
• W2018692561 hasLocation W20186925611 @default.
• W2018692561 hasLocation W20186925612 @default.
• W2018692561 hasLocation W20186925613 @default.
• W2018692561 hasLocation W20186925614 @default.
• W2018692561 hasOpenAccess W2018692561 @default.
• W2018692561 hasPrimaryLocation W20186925611 @default.

• next