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• W2018695959 abstract "Galtier et al. (Science 1999, 283, 220-221) exploit the correlation between the optimal growth temperature in prokaryotes and the G+C content of rRNAs and establish that the last universal common ancestor (LUCA) lived in a mesophilic environment. This result was achieved by estimating the G+C content of the ancestral sequences of the rRNAs of the LUCA through use of a complex Markov model. I have re-analysed their alignments of the rDNAs with maximum parsimony and I have found that their result is not robust and is, in all likelihood, incorrect. In particular, the rRNA ancestral sequences reconstructed with maximum parsimony from these rDNA alignments as well as those reconstructed after eliminating all the sites that turn out to be ambiguous to the parsimony algorithm and to a site-by-site inspection of these alignments, are such as to suggest that the LUCA lived in a thermophilic or hyperthermophilic environment. This finding is also supported by some tRNA ancestral sequences. The main conclusion of this analysis is that if the LUCA was a progenote then the origin of life might have taken place at a high temperature." @default.
• W2018695959 created "2016-06-24" @default.
• W2018695959 creator A5016903088 @default.
• W2018695959 date "2000-04-01" @default.
• W2018695959 modified "2023-09-30" @default.
• W2018695959 title "The Universal Ancestor Lived in a Thermophilic or Hyperthermophilic Environment" @default.
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• W2018695959 doi "https://doi.org/10.1006/jtbi.2000.1086" @default.
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