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• W2018703690 abstract "N-Methyl-d-aspartate, kainate, and quisqualate released endogenous adenosine from superfused slices of rat parietal cortex.N-Methyl-d-aspartate-evoked adenosine release was blocked byd,1-2-amino-5-phosphono-valeric acid and ( + )-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801), indicating that it was receptor-mediated, although it did not show the expected potentiation in the absence of Mg2+. In contrast,N-methyl-d-aspartate-evoked release of [3H]noradrenaline from the same slices was markedly potentiated in Mg2+-free medium. Therefore, the lack of Mg2+ modulation ofN-methyl-d-aspartate-evoked adenosine release was not due to depolarization-induced alleviation of the Mg2+ block in the slices. Kainate-evoked adenosine release was diminished by the non-specific excitatory amino acid antagonist, γ-d-glutamyl-glycine, and kainate- and quisqualate-evoked adenosine release was diminished by 6,7-dinitroquinoxaline-2,3-dione, indicating that these agonists release adenosine by acting atnon-N-methyl-d-aspartate receptors. Tetrodotoxin decreasedN-methyl-d-aspartate- and kainate-evoked adenosine release by 40% and 19% respectively, indicating that release was mediated in part by propagated action potentials in the slices. Total release of adenosine byN-methyl-d-aspartate, kainate or quisqualate was not diminished in the absence of Ca2+. A second exposure to kainate following restoration of Ca2+ to slices previously depolarized in the absence of Ca2+resulted in an amount of adenosine release equal to an initial release by slices in the presence of Ca2+, a result suggesting the presence of separate Ca2+-dependent and Ca2+-independent pools of adenosine. The present experiments demonstrate that activation of all three major subtypes of excitatory amino acid receptors in the cortex releases adenosine, possibly from separate Ca2+-dependent and -independent pools. Adenosine released from the cortex following excitatory amino acid stimulation may, by acting at inhibitory P1 purinoceptors, diminish excitatory neurotransmission and protect against excitotoxicity." @default.
• W2018703690 created "2016-06-24" @default.
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• W2018703690 date "1990-01-01" @default.
• W2018703690 modified "2023-09-27" @default.
• W2018703690 title "N-methyl-d-aspartate, kainate and quisqualate release endogenous adenosine from rat cortical slices" @default.
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• W2018703690 doi "https://doi.org/10.1016/0306-4522(90)90280-h" @default.
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