FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018708103> ?p ?o ?g. }

• W2018708103 abstract "We aimed to evaluate the novel high-affinity and relatively lipophilic CB(1) receptor (CB(1)R) antagonist radioligand [(125)I]SD7015 for SPECT imaging of CB(1)Rs in vivo using the multiplexed multipinhole dedicated small animal SPECT/CT system, NanoSPECT/CT(PLUS) (Mediso, Budapest, Hungary), in knock-out CB(1) receptor knock-out (CB(1)R-/-) and wildtype mice. In order to exclude possible differences in cerebral blood flow between the two types of animals, HMPAO SPECT scans were performed, whereas in order to confirm the brain uptake differences of the radioligand between knock-out mice and wildtype mice, in vivo scans were complemented with ex vivo autoradiographic measurements using the brains of the same animals. With SPECT/CT imaging, we measured the brain uptake of radioactivity, using %SUV (% standardised uptake values) in CB(1)R-/- mice (n=3) and C57BL6 wildtype mice (n=7) under urethane anaesthesia after injecting [(125)I]SD7015 intravenously or intraperitoneally. The Brookhaven Laboratory mouse MRI atlas was fused to the SPECT/CT images by using a combination of rigid and non-rigid algorithms in the Mediso Fusion™ (Mediso, Budapest, Hungary) and VivoQuant (inviCRO, Boston, MA, USA) softwares. Phosphor imager plate autoradiography (ARG) was performed on 4 μm-thin cryostat sections of the excised brains. %SUV was 8.6±3.6 (average±SD) in CB(1)R-/- mice and 22.1±12.4 in wildtype mice between 2 and 4 h after injection (p<0.05). ARG of identically taken sections from wildtype mouse brain showed moderate radioactivity uptake when compared with the in vivo images, with a clear difference between grey matter and white matter, whereas ARG in CB(1)R(-/-) mice showed practically no radioactivity uptake. [(125)I]SD7015 enters the mouse brain in sufficient amount to enable SPECT imaging. Brain radioactivity distribution largely coincides with that of the known CB(1)R expression pattern in rodent brain. We conclude that [(125)I]SD7015 should be a useful SPECT radioligand for studying brain CB(1)R in mouse and rat disease models." @default.
• W2018708103 created "2016-06-24" @default.
• W2018708103 creator A5015721937 @default.
• W2018708103 creator A5022431389 @default.
• W2018708103 creator A5030499753 @default.
• W2018708103 creator A5033422963 @default.
• W2018708103 creator A5048937067 @default.
• W2018708103 creator A5049734226 @default.
• W2018708103 creator A5055589117 @default.
• W2018708103 creator A5068880011 @default.
• W2018708103 creator A5076614620 @default.
• W2018708103 creator A5081327813 @default.
• W2018708103 creator A5084703314 @default.
• W2018708103 date "2013-02-01" @default.
• W2018708103 modified "2023-10-12" @default.
• W2018708103 title "In vivo SPECT and ex vivo autoradiographic brain imaging of the novel selective CB1 receptor antagonist radioligand [125I]SD7015 in CB1 knock-out and wildtype mouse" @default.
• W2018708103 cites W133106046 @default.
• W2018708103 cites W1567718628 @default.
• W2018708103 cites W1836729582 @default.
• W2018708103 cites W1964554113 @default.
• W2018708103 cites W1964569087 @default.
• W2018708103 cites W1967910172 @default.
• W2018708103 cites W1968740815 @default.
• W2018708103 cites W1969592824 @default.
• W2018708103 cites W1973176174 @default.
• W2018708103 cites W1975979611 @default.
• W2018708103 cites W1980826175 @default.
• W2018708103 cites W1980967605 @default.
• W2018708103 cites W1985249962 @default.
• W2018708103 cites W1985366996 @default.
• W2018708103 cites W1986287125 @default.
• W2018708103 cites W1988517047 @default.
• W2018708103 cites W1988800581 @default.
• W2018708103 cites W1989915314 @default.
• W2018708103 cites W1990023400 @default.
• W2018708103 cites W1996444783 @default.
• W2018708103 cites W1998603090 @default.
• W2018708103 cites W2004142971 @default.
• W2018708103 cites W2006474138 @default.
• W2018708103 cites W2007575448 @default.
• W2018708103 cites W2013575848 @default.
• W2018708103 cites W2013961851 @default.
• W2018708103 cites W2020808135 @default.
• W2018708103 cites W2037811574 @default.
• W2018708103 cites W2045507315 @default.
• W2018708103 cites W2045893731 @default.
• W2018708103 cites W2051746299 @default.
• W2018708103 cites W2059421922 @default.
• W2018708103 cites W2060694966 @default.
• W2018708103 cites W2064128689 @default.
• W2018708103 cites W2064358322 @default.
• W2018708103 cites W2065631293 @default.
• W2018708103 cites W2068863154 @default.
• W2018708103 cites W2073116630 @default.
• W2018708103 cites W2074106622 @default.
• W2018708103 cites W2077648124 @default.
• W2018708103 cites W2081629269 @default.
• W2018708103 cites W2088851718 @default.
• W2018708103 cites W2093733740 @default.
• W2018708103 cites W2098730433 @default.
• W2018708103 cites W2104589575 @default.
• W2018708103 cites W2106537627 @default.
• W2018708103 cites W2111866922 @default.
• W2018708103 cites W2126766019 @default.
• W2018708103 cites W2128037951 @default.
• W2018708103 cites W2128957483 @default.
• W2018708103 cites W2130587723 @default.
• W2018708103 cites W2144069251 @default.
• W2018708103 cites W2164341736 @default.
• W2018708103 cites W2168161132 @default.
• W2018708103 cites W2168924839 @default.
• W2018708103 cites W2171584675 @default.
• W2018708103 cites W2171637070 @default.
• W2018708103 cites W2186191997 @default.
• W2018708103 cites W95742801 @default.
• W2018708103 cites W2131697810 @default.
• W2018708103 doi "https://doi.org/10.1016/j.brainresbull.2013.01.001" @default.
• W2018708103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4182908" @default.
• W2018708103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23318272" @default.
• W2018708103 hasPublicationYear "2013" @default.
• W2018708103 type Work @default.
• W2018708103 sameAs 2018708103 @default.
• W2018708103 citedByCount "2" @default.
• W2018708103 countsByYear W20187081032018 @default.
• W2018708103 countsByYear W20187081032020 @default.
• W2018708103 crossrefType "journal-article" @default.
• W2018708103 hasAuthorship W2018708103A5015721937 @default.
• W2018708103 hasAuthorship W2018708103A5022431389 @default.
• W2018708103 hasAuthorship W2018708103A5030499753 @default.
• W2018708103 hasAuthorship W2018708103A5033422963 @default.
• W2018708103 hasAuthorship W2018708103A5048937067 @default.
• W2018708103 hasAuthorship W2018708103A5049734226 @default.
• W2018708103 hasAuthorship W2018708103A5055589117 @default.
• W2018708103 hasAuthorship W2018708103A5068880011 @default.
• W2018708103 hasAuthorship W2018708103A5076614620 @default.
• W2018708103 hasAuthorship W2018708103A5081327813 @default.
• W2018708103 hasAuthorship W2018708103A5084703314 @default.
• W2018708103 hasBestOaLocation W20187081033 @default.
• W2018708103 hasConcept C104317684 @default.
• W2018708103 hasConcept C143065580 @default.

• next