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• W201872065 abstract "Cancer treatments are detrimental to spermatogenesis. This series reviews effects of anticancer therapies on male fertility, current and future approaches to determine sperm health, and gives recommendations for patient management. Cancer treatments are detrimental to spermatogenesis. This series reviews effects of anticancer therapies on male fertility, current and future approaches to determine sperm health, and gives recommendations for patient management. Discuss: You can discuss this article with its authors and with other ASRM members at http://fertstertforum.com/sigmanm-cancer-treatment-spermatogenesis/ Discuss: You can discuss this article with its authors and with other ASRM members at http://fertstertforum.com/sigmanm-cancer-treatment-spermatogenesis/ It is well known that both cancer and cancer therapy may adversely affect male fertility. As treatments for some malignancies become more effective, attention has turned from a focus only on survival, to the quality of life of those that do survive. Part of that equation is the effects of anticancer therapies on male reproduction. The common management strategy for men that may undergo anticancer therapy is sperm cryopreservation prior to therapy. Despite the well-known impairment in spermatogenesis that occurs from chemotherapy and radiation therapy, many men are still not informed about the option of sperm banking. Beyond this most basic tenant, there remains much that is not known about the optimal management of these patients. The accompanying series of articles explore a variety of aspects of anticancer therapy and male reproduction. For those that deal with these patients, an understanding of the basic effects of these therapies is important for proper patient counseling and management. Meistrich reviews the effects of anticancer treatment on spermatogenesis. The time course for impairment of spermatogenesis and return of sperm production are reviewed as well as the effects of different classes of therapy (chemotherapy, radiation therapy, and the increasingly common biologic therapies). An equally important area revolves around the measurement of sperm health and safety. Choy and Brannigan discuss the standard approaches to determining when it is safe to attempt conception after therapy. While the traditional measurement of spermatogenesis is the semen analysis, it is clear that it is not a good measurement of safety; motile sperm may have DNA damage or mutations. As the science of molecular biology has advanced, there are a slew of new approaches that may allow refinement of the assessment of sperm health after anticancer therapy. Dere et al. present a look into the future where assessment of sperm mRNAs, microRNAs, histone modifications, and DNA methylation patterns may allow much more accurate evaluation of sperm quality. Despite the promise of future technologies, those that deal with these patients today need to make recommendations regarding fertility preservation. Nangia et al. synthesize current data to make specific recommendations we may use in clinical practice. Issues such as when to freeze sperm, how many sperm per vial, how to determine whether to use sperm for IUI versus ICSI, how long to use contraception after therapy all need to be addressed despite gaps in our knowledge base. This series of articles broadens our knowledge of male fertility preservation and will hopefully allow us to more accurately counsel our patients." @default.
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• W201872065 date "2013-11-01" @default.
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• W201872065 title "Introduction" @default.
• W201872065 doi "https://doi.org/10.1016/j.fertnstert.2013.09.011" @default.
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