FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018721808> ?p ?o ?g. }

• W2018721808 endingPage "308" @default.
• W2018721808 startingPage "302" @default.
• W2018721808 abstract "Aims Several pathophysiological conditions in the urinary bladder, for example, ischemia/reperfusion and inflammation are characterized by the formation of reactive oxygen species (ROS). The ROS are highly toxic because they can destroy proteins, DNA, and lipids. The aim of this study was to investigate the effect of oxidative stress on excitation-contraction coupling of detrusor smooth muscle. Materials and Methods Smooth muscle strips were dissected from pig urinary bladder and mounted in organ baths. Oxidative stress was mimicked by the addition of Cumene hydroperoxide (CHP), a lipophilic hydroperoxide, to the organ baths. Contractile responses to electrical field stimulation (EFS: 4–32 Hz), carbachol (10−8–3 × 10−5 M), potassium (65.3 mM), and ATP (1 mM) were monitored before and after the addition of CHP. Results Responses of detrusor strips to EFS were for the greater part based on neurogenic stimulation and the release of acetylcholine. CHP diminished contractile responses to EFS and carbachol to the same extent. The pD2 value of the carbachol concentration-response curve decreased significantly after exposure to 0.1 mM, 0.4 mM, 0.8 mM CHP. Furthermore the maximal effect obtained with carbachol was significantly reduced after 0.1 mM, 0.4 mM, and 0.8 mM CHP treatment. Contractions induced by potassium and ATP were significantly less affected by oxidative stress compared to EFS- and carbachol-induced responses of comparable amplitude. Conclusions The results of our study demonstrate that oxidative stress induced by CHP affects pig bladder contractility. The muscarinic receptor signaling system is severely damaged. L-type calcium channels and the contractile system are less affected and cholinergic nerves remain largely unaffected. Neurourol. Urodynam. 26:302–308, 2007. © 2006 Wiley-Liss, Inc." @default.
• W2018721808 created "2016-06-24" @default.
• W2018721808 creator A5009860512 @default.
• W2018721808 creator A5015077426 @default.
• W2018721808 creator A5049359215 @default.
• W2018721808 creator A5060345144 @default.
• W2018721808 creator A5074288572 @default.
• W2018721808 creator A5088584167 @default.
• W2018721808 date "2007-01-01" @default.
• W2018721808 modified "2023-10-16" @default.
• W2018721808 title "Oxidative stress reduces the muscarinic receptor function in the urinary bladder" @default.
• W2018721808 cites W1032376300 @default.
• W2018721808 cites W1631214209 @default.
• W2018721808 cites W1831556795 @default.
• W2018721808 cites W1974781011 @default.
• W2018721808 cites W1975391576 @default.
• W2018721808 cites W1978472569 @default.
• W2018721808 cites W1985015854 @default.
• W2018721808 cites W1985460199 @default.
• W2018721808 cites W1993505627 @default.
• W2018721808 cites W2000375248 @default.
• W2018721808 cites W2001298311 @default.
• W2018721808 cites W2004678119 @default.
• W2018721808 cites W2006067582 @default.
• W2018721808 cites W2007559318 @default.
• W2018721808 cites W2015727883 @default.
• W2018721808 cites W2017353450 @default.
• W2018721808 cites W2030061265 @default.
• W2018721808 cites W2030450267 @default.
• W2018721808 cites W2031547337 @default.
• W2018721808 cites W2035001907 @default.
• W2018721808 cites W2048138051 @default.
• W2018721808 cites W2050948709 @default.
• W2018721808 cites W2053255482 @default.
• W2018721808 cites W2055648589 @default.
• W2018721808 cites W2070679735 @default.
• W2018721808 cites W2079204782 @default.
• W2018721808 cites W2123054862 @default.
• W2018721808 cites W2134696085 @default.
• W2018721808 cites W2137089454 @default.
• W2018721808 cites W2155356085 @default.
• W2018721808 cites W2416589660 @default.
• W2018721808 cites W2468007041 @default.
• W2018721808 cites W4294575919 @default.
• W2018721808 doi "https://doi.org/10.1002/nau.20298" @default.
• W2018721808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16998857" @default.
• W2018721808 hasPublicationYear "2007" @default.
• W2018721808 type Work @default.
• W2018721808 sameAs 2018721808 @default.
• W2018721808 citedByCount "38" @default.
• W2018721808 countsByYear W20187218082012 @default.
• W2018721808 countsByYear W20187218082013 @default.
• W2018721808 countsByYear W20187218082014 @default.
• W2018721808 countsByYear W20187218082015 @default.
• W2018721808 countsByYear W20187218082016 @default.
• W2018721808 countsByYear W20187218082017 @default.
• W2018721808 countsByYear W20187218082018 @default.
• W2018721808 countsByYear W20187218082019 @default.
• W2018721808 countsByYear W20187218082020 @default.
• W2018721808 countsByYear W20187218082022 @default.
• W2018721808 countsByYear W20187218082023 @default.
• W2018721808 crossrefType "journal-article" @default.
• W2018721808 hasAuthorship W2018721808A5009860512 @default.
• W2018721808 hasAuthorship W2018721808A5015077426 @default.
• W2018721808 hasAuthorship W2018721808A5049359215 @default.
• W2018721808 hasAuthorship W2018721808A5060345144 @default.
• W2018721808 hasAuthorship W2018721808A5074288572 @default.
• W2018721808 hasAuthorship W2018721808A5088584167 @default.
• W2018721808 hasConcept C126322002 @default.
• W2018721808 hasConcept C134018914 @default.
• W2018721808 hasConcept C163415756 @default.
• W2018721808 hasConcept C170493617 @default.
• W2018721808 hasConcept C185592680 @default.
• W2018721808 hasConcept C24998067 @default.
• W2018721808 hasConcept C2775910092 @default.
• W2018721808 hasConcept C2776151105 @default.
• W2018721808 hasConcept C2778988552 @default.
• W2018721808 hasConcept C2779762690 @default.
• W2018721808 hasConcept C33789571 @default.
• W2018721808 hasConcept C39133596 @default.
• W2018721808 hasConcept C48349386 @default.
• W2018721808 hasConcept C55493867 @default.
• W2018721808 hasConcept C57600042 @default.
• W2018721808 hasConcept C71924100 @default.
• W2018721808 hasConceptScore W2018721808C126322002 @default.
• W2018721808 hasConceptScore W2018721808C134018914 @default.
• W2018721808 hasConceptScore W2018721808C163415756 @default.
• W2018721808 hasConceptScore W2018721808C170493617 @default.
• W2018721808 hasConceptScore W2018721808C185592680 @default.
• W2018721808 hasConceptScore W2018721808C24998067 @default.
• W2018721808 hasConceptScore W2018721808C2775910092 @default.
• W2018721808 hasConceptScore W2018721808C2776151105 @default.
• W2018721808 hasConceptScore W2018721808C2778988552 @default.
• W2018721808 hasConceptScore W2018721808C2779762690 @default.
• W2018721808 hasConceptScore W2018721808C33789571 @default.
• W2018721808 hasConceptScore W2018721808C39133596 @default.
• W2018721808 hasConceptScore W2018721808C48349386 @default.
• W2018721808 hasConceptScore W2018721808C55493867 @default.

• next