FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018728735> ?p ?o ?g. }

• W2018728735 endingPage "8641" @default.
• W2018728735 startingPage "8637" @default.
• W2018728735 abstract "Effects of opiate receptor antagonists on centrally mediated cardiovascular responses to clonidine and beta-endorphin were studied in urethane-anesthetized spontaneously hypertensive Okamoto-Aoki rats (SHR), normotensive Sprague-Dawley rats, and Sprague-Dawley rats made hypertensive with deoxycorticosterone pivalate/salt. Microinjection of 270 pmol of naloxone into the nucleus tractus solitarii (NTS) significantly inhibited the hypotensive and bradycardic response to 5 nmol of similarly administered clonidine in both SHR and normotensive Sprague-Dawley rats. In SHR, a similar inhibition was observed after the delta-opiate receptor antagonist ICI 174864, but not after the mu-receptor antagonist beta-funaltrexamine (both at 270 pmol, intra-NTS), whereas in normotensive Sprague-Dawley rats, beta-funaltrexamine, but not ICI 174864, was an effective inhibitor. The same pattern of differential inhibition was seen when clonidine was given i.v. and the opiate antagonists were given intracisternally in SHR and Sprague-Dawley rats. Intra-NTS microinjection of 280 fmol of beta-endorphin caused hypotension and bradycardia, and these effects were similarly inhibited by ICI 174864 in SHR and by beta-funaltrexamine in Sprague-Dawley rats. In Sprague-Dawley rats made hypertensive by chronic administration of deoxycorticosterone pivalate and salt, the hypotensive and bradycardic effects of intra-NTS clonidine were inhibited by ICI 174864, but not by beta-funaltrexamine, a pattern similar to that in SHR, but different from that in normotensive Sprague-Dawley rats. These results support the hypothesis that beta-endorphin release and subsequent stimulation of opiate receptors in the NTS are involved in the cardiovascular effects of clonidine in rats. These results further suggest, however, that hypertension regulates the subtype of opiate receptors mediating these effects." @default.
• W2018728735 created "2016-06-24" @default.
• W2018728735 creator A5016248730 @default.
• W2018728735 creator A5026132845 @default.
• W2018728735 date "1987-12-01" @default.
• W2018728735 modified "2023-09-23" @default.
• W2018728735 title "Opiate receptors and the endorphin-mediated cardiovascular effects of clonidine in rats: evidence for hypertension-induced mu-subtype to delta-subtype changes." @default.
• W2018728735 cites W1736873125 @default.
• W2018728735 cites W1852747819 @default.
• W2018728735 cites W1963932315 @default.
• W2018728735 cites W1972826355 @default.
• W2018728735 cites W1974427860 @default.
• W2018728735 cites W1975025905 @default.
• W2018728735 cites W1980075929 @default.
• W2018728735 cites W1981227580 @default.
• W2018728735 cites W1986498669 @default.
• W2018728735 cites W1988975022 @default.
• W2018728735 cites W1991896830 @default.
• W2018728735 cites W1993163653 @default.
• W2018728735 cites W1998044137 @default.
• W2018728735 cites W2003755201 @default.
• W2018728735 cites W2005881152 @default.
• W2018728735 cites W2010531200 @default.
• W2018728735 cites W2010600097 @default.
• W2018728735 cites W2020614462 @default.
• W2018728735 cites W2024110952 @default.
• W2018728735 cites W2028480100 @default.
• W2018728735 cites W2035782493 @default.
• W2018728735 cites W2046856345 @default.
• W2018728735 cites W2050531349 @default.
• W2018728735 cites W2055917824 @default.
• W2018728735 cites W2058525538 @default.
• W2018728735 cites W2075811628 @default.
• W2018728735 cites W2076769955 @default.
• W2018728735 cites W2077766899 @default.
• W2018728735 cites W2094907013 @default.
• W2018728735 cites W2111987861 @default.
• W2018728735 cites W2117213097 @default.
• W2018728735 cites W2122295575 @default.
• W2018728735 cites W2130617969 @default.
• W2018728735 cites W2268690767 @default.
• W2018728735 cites W2296701411 @default.
• W2018728735 doi "https://doi.org/10.1073/pnas.84.23.8637" @default.
• W2018728735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/299601" @default.
• W2018728735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2825200" @default.
• W2018728735 hasPublicationYear "1987" @default.
• W2018728735 type Work @default.
• W2018728735 sameAs 2018728735 @default.
• W2018728735 citedByCount "28" @default.
• W2018728735 countsByYear W20187287352012 @default.
• W2018728735 countsByYear W20187287352013 @default.
• W2018728735 countsByYear W20187287352014 @default.
• W2018728735 crossrefType "journal-article" @default.
• W2018728735 hasAuthorship W2018728735A5016248730 @default.
• W2018728735 hasAuthorship W2018728735A5026132845 @default.
• W2018728735 hasBestOaLocation W20187287352 @default.
• W2018728735 hasConcept C126322002 @default.
• W2018728735 hasConcept C134018914 @default.
• W2018728735 hasConcept C170493617 @default.
• W2018728735 hasConcept C185592680 @default.
• W2018728735 hasConcept C24998067 @default.
• W2018728735 hasConcept C2776885963 @default.
• W2018728735 hasConcept C2778140631 @default.
• W2018728735 hasConcept C2778399450 @default.
• W2018728735 hasConcept C2778750930 @default.
• W2018728735 hasConcept C62525196 @default.
• W2018728735 hasConcept C71924100 @default.
• W2018728735 hasConcept C98274493 @default.
• W2018728735 hasConceptScore W2018728735C126322002 @default.
• W2018728735 hasConceptScore W2018728735C134018914 @default.
• W2018728735 hasConceptScore W2018728735C170493617 @default.
• W2018728735 hasConceptScore W2018728735C185592680 @default.
• W2018728735 hasConceptScore W2018728735C24998067 @default.
• W2018728735 hasConceptScore W2018728735C2776885963 @default.
• W2018728735 hasConceptScore W2018728735C2778140631 @default.
• W2018728735 hasConceptScore W2018728735C2778399450 @default.
• W2018728735 hasConceptScore W2018728735C2778750930 @default.
• W2018728735 hasConceptScore W2018728735C62525196 @default.
• W2018728735 hasConceptScore W2018728735C71924100 @default.
• W2018728735 hasConceptScore W2018728735C98274493 @default.
• W2018728735 hasIssue "23" @default.
• W2018728735 hasLocation W20187287351 @default.
• W2018728735 hasLocation W20187287352 @default.
• W2018728735 hasLocation W20187287353 @default.
• W2018728735 hasOpenAccess W2018728735 @default.
• W2018728735 hasPrimaryLocation W20187287351 @default.
• W2018728735 hasRelatedWork W1976030186 @default.
• W2018728735 hasRelatedWork W2002409632 @default.
• W2018728735 hasRelatedWork W2032031959 @default.
• W2018728735 hasRelatedWork W2042834119 @default.
• W2018728735 hasRelatedWork W2053940272 @default.
• W2018728735 hasRelatedWork W2056150879 @default.
• W2018728735 hasRelatedWork W2060367584 @default.
• W2018728735 hasRelatedWork W2064169706 @default.
• W2018728735 hasRelatedWork W2068948430 @default.
• W2018728735 hasRelatedWork W2088121632 @default.
• W2018728735 hasVolume "84" @default.
• W2018728735 isParatext "false" @default.

• next