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- W2018730560 abstract "Necrotizing enterocolitis (NEC) continues to be a devastating inflammatory disease of the newborn intestine. Despite advances in management, morbidity and mortality remain high. While it is clear that intestinal ischemia plays a large role in disease pathogenesis, attempts to link NEC to intestinal macrovascular derangement have been largely unsuccessful. More recently, there has been a concerted effort to characterize the pathologic changes of the intestinal microcirculation in response to intestinal injury, including NEC. This microcirculatory regulation is controlled by a balance of vasoconstrictor and vasodilator forces. Vasoconstriction is mediated primarily by endothelin-1 (ET-1), while vasodilation is mediated primarily by nitric oxide (NO). These chemical mediators have been implicated in many aspects of intestinal ischemic injury and NEC, with the balance shifting toward increased vasoconstriction associated with intestinal injury. With a proper understanding of these antagonistic forces, potential therapeutic avenues may result from improving this pathologic microcirculatory dysregulation." @default.
- W2018730560 created "2016-06-24" @default.
- W2018730560 creator A5009266124 @default.
- W2018730560 creator A5046256982 @default.
- W2018730560 date "2013-05-01" @default.
- W2018730560 modified "2023-09-25" @default.
- W2018730560 title "The role of the intestinal microcirculation in necrotizing enterocolitis" @default.
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- W2018730560 doi "https://doi.org/10.1053/j.sempedsurg.2013.01.004" @default.
- W2018730560 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3646103" @default.
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