FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018732549> ?p ?o ?g. }

• W2018732549 endingPage "e105703" @default.
• W2018732549 startingPage "e105703" @default.
• W2018732549 abstract "T-cell exhaustion seems to play a critical role in CD8+ T-cell dysfunction during chronic viral infections. However, up to now little is known about the mechanisms underlying CD4+ T-cell dysfunction during chronic hepatitis B virus (CHB) infection and the role of inhibitory molecules such as programmed death 1 (PD-1) for CD4+ T-cell failure.The expression of multiple inhibitory molecules such as PD-1, CTLA-4, TIM-3, CD244, KLRG1 and markers defining the grade of T-cell differentiation as CCR7, CD45RA, CD57 and CD127 were analyzed on virus-specific CD4+ T-cells from peripheral blood using a newly established DRB1*01-restricted MHC class II Tetramer. Effects of in vitro PD-L1/2 blockade were defined by investigating changes in CD4+ T-cell proliferation and cytokine production.CD4+ T-cell responses during chronic HBV infection was characterized by reduced Tetramer+CD4+ T-cell frequencies, effector memory phenotype, sustained PD-1 but low levels of CTLA-4, TIM-3, KLRG1 and CD244 expression. PD-1 blockade revealed individualized patterns of in vitro responsiveness with partly increased IFN-γ, IL-2 and TNF-α secretion as well as enhanced CD4+ T-cell expansion almost in treated patients with viral control.HBV-specific CD4+ T-cells are reliably detectable during different courses of HBV infection by MHC class II Tetramer technology. CD4+ T-cell dysfunction during chronic HBV is basically linked to strong PD-1 upregulation but absent coregulation of multiple inhibitory receptors. PD-L1/2 neutralization partly leads to enhanced CD4+ T-cell functionality with heterogeneous patterns of CD4+ T-cell rejunivation." @default.
• W2018732549 created "2016-06-24" @default.
• W2018732549 creator A5007241760 @default.
• W2018732549 creator A5011530744 @default.
• W2018732549 creator A5014615779 @default.
• W2018732549 creator A5030380569 @default.
• W2018732549 creator A5036331681 @default.
• W2018732549 creator A5036982493 @default.
• W2018732549 creator A5043829341 @default.
• W2018732549 creator A5044524026 @default.
• W2018732549 creator A5061218663 @default.
• W2018732549 creator A5062793154 @default.
• W2018732549 creator A5070805632 @default.
• W2018732549 creator A5075459069 @default.
• W2018732549 creator A5086134082 @default.
• W2018732549 creator A5089706933 @default.
• W2018732549 creator A5089829401 @default.
• W2018732549 date "2014-08-21" @default.
• W2018732549 modified "2023-10-18" @default.
• W2018732549 title "Inhibitory Phenotype of HBV-Specific CD4+ T-Cells Is Characterized by High PD-1 Expression but Absent Coregulation of Multiple Inhibitory Molecules" @default.
• W2018732549 cites W1975753196 @default.
• W2018732549 cites W1979269943 @default.
• W2018732549 cites W1981480494 @default.
• W2018732549 cites W1990058709 @default.
• W2018732549 cites W1990213501 @default.
• W2018732549 cites W2015035059 @default.
• W2018732549 cites W2033239466 @default.
• W2018732549 cites W2034116082 @default.
• W2018732549 cites W2036402301 @default.
• W2018732549 cites W2037610638 @default.
• W2018732549 cites W2044757144 @default.
• W2018732549 cites W2046828081 @default.
• W2018732549 cites W2053841647 @default.
• W2018732549 cites W2054119257 @default.
• W2018732549 cites W2059384462 @default.
• W2018732549 cites W2064033218 @default.
• W2018732549 cites W2077116159 @default.
• W2018732549 cites W2077940506 @default.
• W2018732549 cites W2083755629 @default.
• W2018732549 cites W2086014112 @default.
• W2018732549 cites W2088541970 @default.
• W2018732549 cites W2099468505 @default.
• W2018732549 cites W2104966044 @default.
• W2018732549 cites W2121339743 @default.
• W2018732549 cites W2130992177 @default.
• W2018732549 cites W2139496066 @default.
• W2018732549 cites W2144373841 @default.
• W2018732549 cites W2152095262 @default.
• W2018732549 cites W2152441233 @default.
• W2018732549 cites W2159896543 @default.
• W2018732549 cites W4245799938 @default.
• W2018732549 doi "https://doi.org/10.1371/journal.pone.0105703" @default.
• W2018732549 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4140833" @default.
• W2018732549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25144233" @default.
• W2018732549 hasPublicationYear "2014" @default.
• W2018732549 type Work @default.
• W2018732549 sameAs 2018732549 @default.
• W2018732549 citedByCount "58" @default.
• W2018732549 countsByYear W20187325492014 @default.
• W2018732549 countsByYear W20187325492015 @default.
• W2018732549 countsByYear W20187325492016 @default.
• W2018732549 countsByYear W20187325492017 @default.
• W2018732549 countsByYear W20187325492018 @default.
• W2018732549 countsByYear W20187325492019 @default.
• W2018732549 countsByYear W20187325492020 @default.
• W2018732549 countsByYear W20187325492021 @default.
• W2018732549 countsByYear W20187325492022 @default.
• W2018732549 countsByYear W20187325492023 @default.
• W2018732549 crossrefType "journal-article" @default.
• W2018732549 hasAuthorship W2018732549A5007241760 @default.
• W2018732549 hasAuthorship W2018732549A5011530744 @default.
• W2018732549 hasAuthorship W2018732549A5014615779 @default.
• W2018732549 hasAuthorship W2018732549A5030380569 @default.
• W2018732549 hasAuthorship W2018732549A5036331681 @default.
• W2018732549 hasAuthorship W2018732549A5036982493 @default.
• W2018732549 hasAuthorship W2018732549A5043829341 @default.
• W2018732549 hasAuthorship W2018732549A5044524026 @default.
• W2018732549 hasAuthorship W2018732549A5061218663 @default.
• W2018732549 hasAuthorship W2018732549A5062793154 @default.
• W2018732549 hasAuthorship W2018732549A5070805632 @default.
• W2018732549 hasAuthorship W2018732549A5075459069 @default.
• W2018732549 hasAuthorship W2018732549A5086134082 @default.
• W2018732549 hasAuthorship W2018732549A5089706933 @default.
• W2018732549 hasAuthorship W2018732549A5089829401 @default.
• W2018732549 hasBestOaLocation W20187325491 @default.
• W2018732549 hasConcept C123982805 @default.
• W2018732549 hasConcept C154317977 @default.
• W2018732549 hasConcept C159047783 @default.
• W2018732549 hasConcept C167672396 @default.
• W2018732549 hasConcept C170627219 @default.
• W2018732549 hasConcept C202751555 @default.
• W2018732549 hasConcept C203014093 @default.
• W2018732549 hasConcept C2522874641 @default.
• W2018732549 hasConcept C2776090121 @default.
• W2018732549 hasConcept C2780593183 @default.
• W2018732549 hasConcept C54355233 @default.
• W2018732549 hasConcept C79484868 @default.
• W2018732549 hasConcept C86803240 @default.

• next