Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018738038> ?p ?o ?g. }
- W2018738038 endingPage "1423" @default.
- W2018738038 startingPage "1413" @default.
- W2018738038 abstract "Transport and biosynthesis of folate and its derivatives are frequently controlled by the tetrahydrofolate (THF) riboswitch in Firmicutes. We have solved the crystal structure of the THF riboswitch aptamer in complex with folinic acid, a THF analog. Uniquely, this structure reveals two molecules of folinic acid binding to a single structured domain. These two sites interact with ligand in a similar fashion, primarily through recognition of the reduced pterin moiety. 7-deazaguanine, a soluble analog of guanine, binds the riboswitch with nearly the same affinity as its natural effector. However, 7-deazaguanine effects transcriptional termination to a substantially lesser degree than folinic acid, suggesting that the cellular guanine pool does not act upon the THF riboswitch. Under physiological conditions the ligands display strong cooperative binding, with one of the two sites playing a greater role in eliciting the regulatory response, which suggests that the second site may play another functional role." @default.
- W2018738038 created "2016-06-24" @default.
- W2018738038 creator A5004642468 @default.
- W2018738038 creator A5017593523 @default.
- W2018738038 creator A5034743607 @default.
- W2018738038 creator A5074049459 @default.
- W2018738038 date "2011-10-01" @default.
- W2018738038 modified "2023-10-14" @default.
- W2018738038 title "The Structure of a Tetrahydrofolate-Sensing Riboswitch Reveals Two Ligand Binding Sites in a Single Aptamer" @default.
- W2018738038 cites W1560820522 @default.
- W2018738038 cites W1880629566 @default.
- W2018738038 cites W1968058281 @default.
- W2018738038 cites W1972533328 @default.
- W2018738038 cites W1974470730 @default.
- W2018738038 cites W1974892165 @default.
- W2018738038 cites W1976067984 @default.
- W2018738038 cites W1984357954 @default.
- W2018738038 cites W1985810589 @default.
- W2018738038 cites W1987262986 @default.
- W2018738038 cites W1987920087 @default.
- W2018738038 cites W2003352861 @default.
- W2018738038 cites W2004235182 @default.
- W2018738038 cites W2005665960 @default.
- W2018738038 cites W2006922696 @default.
- W2018738038 cites W2023447708 @default.
- W2018738038 cites W2025522633 @default.
- W2018738038 cites W2025706856 @default.
- W2018738038 cites W2030289208 @default.
- W2018738038 cites W2034992185 @default.
- W2018738038 cites W2039134294 @default.
- W2018738038 cites W2041053455 @default.
- W2018738038 cites W2042366342 @default.
- W2018738038 cites W2049105226 @default.
- W2018738038 cites W2049912773 @default.
- W2018738038 cites W2050665195 @default.
- W2018738038 cites W2056230513 @default.
- W2018738038 cites W2067810191 @default.
- W2018738038 cites W2074948884 @default.
- W2018738038 cites W2080911376 @default.
- W2018738038 cites W2082192988 @default.
- W2018738038 cites W2085356493 @default.
- W2018738038 cites W2085877774 @default.
- W2018738038 cites W2086708241 @default.
- W2018738038 cites W2088267546 @default.
- W2018738038 cites W2091200271 @default.
- W2018738038 cites W2106462936 @default.
- W2018738038 cites W2106478835 @default.
- W2018738038 cites W2107208446 @default.
- W2018738038 cites W2109140064 @default.
- W2018738038 cites W2109184569 @default.
- W2018738038 cites W2114010587 @default.
- W2018738038 cites W2116689021 @default.
- W2018738038 cites W2130097072 @default.
- W2018738038 cites W2131948524 @default.
- W2018738038 cites W2137491597 @default.
- W2018738038 cites W2144081223 @default.
- W2018738038 cites W2151596277 @default.
- W2018738038 cites W2154379876 @default.
- W2018738038 cites W2157052506 @default.
- W2018738038 cites W2163880078 @default.
- W2018738038 cites W2165961683 @default.
- W2018738038 cites W2167955222 @default.
- W2018738038 cites W2403912335 @default.
- W2018738038 cites W349978335 @default.
- W2018738038 cites W4244423099 @default.
- W2018738038 doi "https://doi.org/10.1016/j.str.2011.06.019" @default.
- W2018738038 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3196276" @default.
- W2018738038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21906956" @default.
- W2018738038 hasPublicationYear "2011" @default.
- W2018738038 type Work @default.
- W2018738038 sameAs 2018738038 @default.
- W2018738038 citedByCount "117" @default.
- W2018738038 countsByYear W20187380382012 @default.
- W2018738038 countsByYear W20187380382013 @default.
- W2018738038 countsByYear W20187380382014 @default.
- W2018738038 countsByYear W20187380382015 @default.
- W2018738038 countsByYear W20187380382016 @default.
- W2018738038 countsByYear W20187380382017 @default.
- W2018738038 countsByYear W20187380382018 @default.
- W2018738038 countsByYear W20187380382019 @default.
- W2018738038 countsByYear W20187380382020 @default.
- W2018738038 countsByYear W20187380382021 @default.
- W2018738038 countsByYear W20187380382022 @default.
- W2018738038 countsByYear W20187380382023 @default.
- W2018738038 crossrefType "journal-article" @default.
- W2018738038 hasAuthorship W2018738038A5004642468 @default.
- W2018738038 hasAuthorship W2018738038A5017593523 @default.
- W2018738038 hasAuthorship W2018738038A5034743607 @default.
- W2018738038 hasAuthorship W2018738038A5074049459 @default.
- W2018738038 hasBestOaLocation W20187380381 @default.
- W2018738038 hasConcept C104317684 @default.
- W2018738038 hasConcept C107824862 @default.
- W2018738038 hasConcept C116569031 @default.
- W2018738038 hasConcept C128972844 @default.
- W2018738038 hasConcept C148625055 @default.
- W2018738038 hasConcept C170493617 @default.
- W2018738038 hasConcept C181199279 @default.
- W2018738038 hasConcept C185592680 @default.