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- W2018749063 abstract "Amphibian defensive skin secretions are known to contain a plethora of biologically-active peptides that are often structural and functional analogues of vertebrate neuropeptides. Here we report the structures of two invertebrate neuropeptide analogues, IPPQFMRF amide (IF-8 amide) and EGDEDEFLRF amide (EF-10 amide), from the defensive skin secretions of two different species of African hyperoliid frogs, Kassina maculata and Phylictimantis verrucosus, respectively. These represent the first canonical FMRF amide-related peptides (FaRPs) from a vertebrate source. The cDNA encoding IF-8 amide was cloned from a skin secretion library and found to contain a single copy of the peptide located at the C-terminus of a 58 amino acid residue open-reading frame. These data extend the potential targets of the defensive arsenal of amphibian tegumental secretions to parasitic/predatory invertebrates and the novel peptides described may represent the first vertebrate peptidic endectocides." @default.
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- W2018749063 date "2009-06-01" @default.
- W2018749063 modified "2023-10-16" @default.
- W2018749063 title "FMRFamide-related peptides (FaRPs): A new family of peptides from amphibian defensive skin secretions" @default.
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- W2018749063 doi "https://doi.org/10.1016/j.bbrc.2009.04.002" @default.
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