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• W2018755526 abstract "CD44 is a ubiquitous surface molecule that exists as a number of isoforms, generated by alternative splicing of 10 variant exons. Little is known about the expression and function of the variant isoforms, except that certain isoforms may play a role in cancer metastasis. We produced mAbs against CD44 variant regions encoded by exons 4v, 6v, and 9v, by immunizing mice with a fusion protein spanning variant exons 3v to 10v. A comprehensive analysis of human tissues revealed that CD44 variant isoforms were expressed widely throughout the body, principally by epithelial cells. However there was differential expression of CD44 variant exons by different epithelia. Most epithelia expressed exon 9v, but much fewer expressed 6v or 4v. The regions of epithelia that expressed the highest levels of the variant isoforms were the generative cells, particularly the basal cells of stratified squamous epithelium, and of glandular epithelium. CD44 variant isoforms were also expressed differentially by leukocytes, with CD44-9v expressed at very low levels and CD44-6v and 4v virtually absent. However, CD44-9v and CD44-6v were the main variants that were transiently upregulated on T cells after mitogenic stimulation and on myelomonocytic cell lines by TNF alpha and IFN gamma treatment. Some epithelial cell lines could preferentially upregulate CD44-6v upon IFN gamma incubation. These results show that CD44 variant isoforms are expressed much more widely than first appreciated, and that expression of the variant isoforms on some cell types can be modulated by particular cytokines." @default.
• W2018755526 created "2016-06-24" @default.
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• W2018755526 creator A5089867476 @default.
• W2018755526 date "1994-01-01" @default.
• W2018755526 modified "2023-10-10" @default.
• W2018755526 title "Expression and modulation of CD44 variant isoforms in humans" @default.
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• W2018755526 doi "https://doi.org/10.1083/jcb.124.1.71" @default.
• W2018755526 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2119889" @default.
• W2018755526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7507492" @default.
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