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- W2018755826 abstract "1. The structures, including stereochemistry, of the two major metabolites of pravastatin sodium in an isolated rat hepatocyte system, i.e. the 4′aaL-glutathione conjugate (CM-1) and the 3′,5′-dihydrodiol (CM-2), were determined by one- and two-dimensional n.m.r. spectroscopy2. The structures of two synthetic pravastatin epoxides, possible precursors of the metabolites, were also established.3. One of the synthetic epoxides, 4′aβ,5′β-epoxide was converted to the pravastatin metabolite, 4′aaL-glutathione conjugate (CM-1) by a rat liver cytosol system and is proposed as the common metabolic intermediate between pravastatin sodium and the metabolites, CM-1 and CM-2." @default.
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- W2018755826 date "1991-01-01" @default.
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- W2018755826 title "Metabolism of pravastatin sodium in isolated rat hepatocytes. II. Structure elucidation of the metabolites by n.m.r. spectroscopy" @default.
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- W2018755826 doi "https://doi.org/10.3109/00498259109039469" @default.
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