FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018757508> ?p ?o ?g. }

• W2018757508 endingPage "1010" @default.
• W2018757508 startingPage "1004" @default.
• W2018757508 abstract "Angiotensin (Ang)-(1–7), a metabolite of AngI and AngII, is a counter-regulatory mediator of AngII. In the present study, we investigated the effects of Ang-(1–7) on AngII-induced apoptosis in human umbilical vein endothelial cells (HUVEC). To this end, HUVEC were pretreated with 10−9, 10−8, 10−7 or 10−6 mol/L Ang-(1–7) at for 30 min before being stimulated with 10−6 mol/L Ang-II for another 24 h. Acridine orange/ethidium bromide and propidium iodide staining were used to analyse the effects of Ang-(1–7) on AngII-induced apoptosis. Alone, 10−6 mol/L Ang-(1–7) had no effect on the apoptosis of HUVEC following exposure of cells for 30 min, whereas AngII (10−6 mol/L, 24 h) significantly enhanced the number of apoptotic cells (P < 0.01). The AngII-induced apoptosis of HUVEC was suppressed by 10−9–10−6 mol/L Ang-(1–7). The anti-apoptotic effects of Ang-(1–7) were almost completely abolished by A-779 (10−6 mol/L, 30 min), a specific Mas receptor antagonist. In addition, Ang-(1–7) inhibited AngII-induced accumulation of cleaved caspase 3 and enhanced the expression of the anti-apoptotic factor Bcl-2 at both the mRNA and protein levels. Angiotensin II upregulated the expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which is involved in endothelial apoptosis, at both the mRNA and protein levels. This effect was blocked by Ang-(1–7) in a concentration-dependent manner, although A-779 almost completely reversed Ang-(1–7)-mediated inhibition of AngII-induced upregulation of LOX-1. Silencing of LOX-1 using short interference RNA enhanced the protective effects of Ang-(1–7) against AngII-induced apoptosis in HUVEC. Together, the results suggest that Ang-(1–7) ameliorates AngII-induced apoptosis of HUVEC at least in part by suppressing LOX-1 expression." @default.
• W2018757508 created "2016-06-24" @default.
• W2018757508 creator A5006605583 @default.
• W2018757508 creator A5009679536 @default.
• W2018757508 creator A5029636776 @default.
• W2018757508 creator A5045216911 @default.
• W2018757508 creator A5051212432 @default.
• W2018757508 creator A5068813813 @default.
• W2018757508 creator A5083548222 @default.
• W2018757508 creator A5084198300 @default.
• W2018757508 creator A5084300721 @default.
• W2018757508 date "2012-11-26" @default.
• W2018757508 modified "2023-09-26" @default.
• W2018757508 title "Angiotensin-(1-7) treatment ameliorates angiotensin II-induced apoptosis of human umbilical vein endothelial cells" @default.
• W2018757508 cites W17992636 @default.
• W2018757508 cites W1964599275 @default.
• W2018757508 cites W1970198376 @default.
• W2018757508 cites W1970661198 @default.
• W2018757508 cites W1986542431 @default.
• W2018757508 cites W2003181513 @default.
• W2018757508 cites W2027675986 @default.
• W2018757508 cites W2027869415 @default.
• W2018757508 cites W2036481637 @default.
• W2018757508 cites W2060629558 @default.
• W2018757508 cites W2061306207 @default.
• W2018757508 cites W2067488964 @default.
• W2018757508 cites W2078051927 @default.
• W2018757508 cites W2098816300 @default.
• W2018757508 cites W2099901191 @default.
• W2018757508 cites W2126820133 @default.
• W2018757508 cites W2129656867 @default.
• W2018757508 cites W2130600499 @default.
• W2018757508 cites W2134412947 @default.
• W2018757508 cites W2136571597 @default.
• W2018757508 cites W2139739531 @default.
• W2018757508 cites W2157603347 @default.
• W2018757508 cites W2169046108 @default.
• W2018757508 cites W2411807040 @default.
• W2018757508 doi "https://doi.org/10.1111/1440-1681.12016" @default.
• W2018757508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23030315" @default.
• W2018757508 hasPublicationYear "2012" @default.
• W2018757508 type Work @default.
• W2018757508 sameAs 2018757508 @default.
• W2018757508 citedByCount "25" @default.
• W2018757508 countsByYear W20187575082012 @default.
• W2018757508 countsByYear W20187575082013 @default.
• W2018757508 countsByYear W20187575082014 @default.
• W2018757508 countsByYear W20187575082015 @default.
• W2018757508 countsByYear W20187575082016 @default.
• W2018757508 countsByYear W20187575082017 @default.
• W2018757508 countsByYear W20187575082018 @default.
• W2018757508 countsByYear W20187575082019 @default.
• W2018757508 countsByYear W20187575082020 @default.
• W2018757508 countsByYear W20187575082021 @default.
• W2018757508 countsByYear W20187575082023 @default.
• W2018757508 crossrefType "journal-article" @default.
• W2018757508 hasAuthorship W2018757508A5006605583 @default.
• W2018757508 hasAuthorship W2018757508A5009679536 @default.
• W2018757508 hasAuthorship W2018757508A5029636776 @default.
• W2018757508 hasAuthorship W2018757508A5045216911 @default.
• W2018757508 hasAuthorship W2018757508A5051212432 @default.
• W2018757508 hasAuthorship W2018757508A5068813813 @default.
• W2018757508 hasAuthorship W2018757508A5083548222 @default.
• W2018757508 hasAuthorship W2018757508A5084198300 @default.
• W2018757508 hasAuthorship W2018757508A5084300721 @default.
• W2018757508 hasConcept C126322002 @default.
• W2018757508 hasConcept C134018914 @default.
• W2018757508 hasConcept C153911025 @default.
• W2018757508 hasConcept C170493617 @default.
• W2018757508 hasConcept C185592680 @default.
• W2018757508 hasConcept C190283241 @default.
• W2018757508 hasConcept C202751555 @default.
• W2018757508 hasConcept C2775934118 @default.
• W2018757508 hasConcept C2777411675 @default.
• W2018757508 hasConcept C2908929049 @default.
• W2018757508 hasConcept C31573885 @default.
• W2018757508 hasConcept C55493867 @default.
• W2018757508 hasConcept C71924100 @default.
• W2018757508 hasConcept C86803240 @default.
• W2018757508 hasConceptScore W2018757508C126322002 @default.
• W2018757508 hasConceptScore W2018757508C134018914 @default.
• W2018757508 hasConceptScore W2018757508C153911025 @default.
• W2018757508 hasConceptScore W2018757508C170493617 @default.
• W2018757508 hasConceptScore W2018757508C185592680 @default.
• W2018757508 hasConceptScore W2018757508C190283241 @default.
• W2018757508 hasConceptScore W2018757508C202751555 @default.
• W2018757508 hasConceptScore W2018757508C2775934118 @default.
• W2018757508 hasConceptScore W2018757508C2777411675 @default.
• W2018757508 hasConceptScore W2018757508C2908929049 @default.
• W2018757508 hasConceptScore W2018757508C31573885 @default.
• W2018757508 hasConceptScore W2018757508C55493867 @default.
• W2018757508 hasConceptScore W2018757508C71924100 @default.
• W2018757508 hasConceptScore W2018757508C86803240 @default.
• W2018757508 hasIssue "12" @default.
• W2018757508 hasLocation W20187575081 @default.
• W2018757508 hasLocation W20187575082 @default.
• W2018757508 hasOpenAccess W2018757508 @default.
• W2018757508 hasPrimaryLocation W20187575081 @default.

• next