FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018758055> ?p ?o ?g. }

• W2018758055 endingPage "e1002638" @default.
• W2018758055 startingPage "e1002638" @default.
• W2018758055 abstract "NOD-like receptor (NLR) proteins (Nlrps) are cytosolic sensors responsible for detection of pathogen and danger-associated molecular patterns through unknown mechanisms. Their activation in response to a wide range of intracellular danger signals leads to formation of the inflammasome, caspase-1 activation, rapid programmed cell death (pyroptosis) and maturation of IL-1β and IL-18. Anthrax lethal toxin (LT) induces the caspase-1-dependent pyroptosis of mouse and rat macrophages isolated from certain inbred rodent strains through activation of the NOD-like receptor (NLR) Nlrp1 inflammasome. Here we show that LT cleaves rat Nlrp1 and this cleavage is required for toxin-induced inflammasome activation, IL-1 β release, and macrophage pyroptosis. These results identify both a previously unrecognized mechanism of activation of an NLR and a new, physiologically relevant protein substrate of LT." @default.
• W2018758055 created "2016-06-24" @default.
• W2018758055 creator A5001819434 @default.
• W2018758055 creator A5004197275 @default.
• W2018758055 creator A5019841694 @default.
• W2018758055 creator A5023118133 @default.
• W2018758055 creator A5027668236 @default.
• W2018758055 creator A5029675337 @default.
• W2018758055 creator A5043746736 @default.
• W2018758055 creator A5051121734 @default.
• W2018758055 creator A5053629546 @default.
• W2018758055 date "2012-03-29" @default.
• W2018758055 modified "2023-10-01" @default.
• W2018758055 title "Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome" @default.
• W2018758055 cites W1965623265 @default.
• W2018758055 cites W1974917488 @default.
• W2018758055 cites W1980847339 @default.
• W2018758055 cites W1985716934 @default.
• W2018758055 cites W1988197452 @default.
• W2018758055 cites W2001095885 @default.
• W2018758055 cites W2006695188 @default.
• W2018758055 cites W2014719030 @default.
• W2018758055 cites W2015129202 @default.
• W2018758055 cites W2023324232 @default.
• W2018758055 cites W2023706277 @default.
• W2018758055 cites W2033207435 @default.
• W2018758055 cites W2052874989 @default.
• W2018758055 cites W2114442515 @default.
• W2018758055 cites W2114769428 @default.
• W2018758055 cites W2118800225 @default.
• W2018758055 cites W2128718510 @default.
• W2018758055 cites W2143792029 @default.
• W2018758055 cites W2157490013 @default.
• W2018758055 doi "https://doi.org/10.1371/journal.ppat.1002638" @default.
• W2018758055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3315489" @default.
• W2018758055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22479187" @default.
• W2018758055 hasPublicationYear "2012" @default.
• W2018758055 type Work @default.
• W2018758055 sameAs 2018758055 @default.
• W2018758055 citedByCount "275" @default.
• W2018758055 countsByYear W20187580552012 @default.
• W2018758055 countsByYear W20187580552013 @default.
• W2018758055 countsByYear W20187580552014 @default.
• W2018758055 countsByYear W20187580552015 @default.
• W2018758055 countsByYear W20187580552016 @default.
• W2018758055 countsByYear W20187580552017 @default.
• W2018758055 countsByYear W20187580552018 @default.
• W2018758055 countsByYear W20187580552019 @default.
• W2018758055 countsByYear W20187580552020 @default.
• W2018758055 countsByYear W20187580552021 @default.
• W2018758055 countsByYear W20187580552022 @default.
• W2018758055 countsByYear W20187580552023 @default.
• W2018758055 crossrefType "journal-article" @default.
• W2018758055 hasAuthorship W2018758055A5001819434 @default.
• W2018758055 hasAuthorship W2018758055A5004197275 @default.
• W2018758055 hasAuthorship W2018758055A5019841694 @default.
• W2018758055 hasAuthorship W2018758055A5023118133 @default.
• W2018758055 hasAuthorship W2018758055A5027668236 @default.
• W2018758055 hasAuthorship W2018758055A5029675337 @default.
• W2018758055 hasAuthorship W2018758055A5043746736 @default.
• W2018758055 hasAuthorship W2018758055A5051121734 @default.
• W2018758055 hasAuthorship W2018758055A5053629546 @default.
• W2018758055 hasBestOaLocation W20187580551 @default.
• W2018758055 hasConcept C104317684 @default.
• W2018758055 hasConcept C139964883 @default.
• W2018758055 hasConcept C151730666 @default.
• W2018758055 hasConcept C170493617 @default.
• W2018758055 hasConcept C17172800 @default.
• W2018758055 hasConcept C175156509 @default.
• W2018758055 hasConcept C176912530 @default.
• W2018758055 hasConcept C181199279 @default.
• W2018758055 hasConcept C185592680 @default.
• W2018758055 hasConcept C190283241 @default.
• W2018758055 hasConcept C2777209026 @default.
• W2018758055 hasConcept C2777367657 @default.
• W2018758055 hasConcept C31573885 @default.
• W2018758055 hasConcept C43369102 @default.
• W2018758055 hasConcept C55493867 @default.
• W2018758055 hasConcept C55851684 @default.
• W2018758055 hasConcept C79879829 @default.
• W2018758055 hasConcept C86803240 @default.
• W2018758055 hasConcept C89423630 @default.
• W2018758055 hasConcept C95444343 @default.
• W2018758055 hasConcept C98424977 @default.
• W2018758055 hasConcept C98539663 @default.
• W2018758055 hasConceptScore W2018758055C104317684 @default.
• W2018758055 hasConceptScore W2018758055C139964883 @default.
• W2018758055 hasConceptScore W2018758055C151730666 @default.
• W2018758055 hasConceptScore W2018758055C170493617 @default.
• W2018758055 hasConceptScore W2018758055C17172800 @default.
• W2018758055 hasConceptScore W2018758055C175156509 @default.
• W2018758055 hasConceptScore W2018758055C176912530 @default.
• W2018758055 hasConceptScore W2018758055C181199279 @default.
• W2018758055 hasConceptScore W2018758055C185592680 @default.
• W2018758055 hasConceptScore W2018758055C190283241 @default.
• W2018758055 hasConceptScore W2018758055C2777209026 @default.
• W2018758055 hasConceptScore W2018758055C2777367657 @default.
• W2018758055 hasConceptScore W2018758055C31573885 @default.

• next