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- W2018761239 abstract "Biopsy material from human gliomas obtained during neurosurgery was used to investigate whether pathological human brain tissue is capable of producing kynurenic acid (KYNA), a natural brain metabolite which can act as an antagonist at excitatory amino acid receptors. Upon in vitro exposure to 40, 200 or 1000 microM L-kynurenine, the immediate bioprecursor of KYNA, freshly prepared tissue slices in a dose-dependent fashion produced KYNA which was detected in the incubation medium. De novo synthesized KYNA was identified by several chromatographic procedures. Astrocytomas produced significantly more KYNA than glioblastomas." @default.
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- W2018761239 date "1990-10-01" @default.
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- W2018761239 title "Kynurenic acid synthesis by human glioma" @default.
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- W2018761239 doi "https://doi.org/10.1016/0022-510x(90)90198-v" @default.
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