Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018762489> ?p ?o ?g. }
- W2018762489 endingPage "e0121007" @default.
- W2018762489 startingPage "e0121007" @default.
- W2018762489 abstract "Background Gαq protein carboxyl terminus imitation polypeptide (GCIP)-27 has been shown to alleviate pathological cardiomyocyte hypertrophy induced by various factors. Pathological cardiac hypertrophy increases the morbidity and mortality of cardiovascular diseases while it compensates for poor heart function. This study was designed to investigate the effects of GCIP-27 on heart function in rats with heart failure induced by doxorubicin. Methods and Results Forty-eight rats were randomly divided into the following six groups receiving vehicle (control), doxorubicin (Dox), losartan (6 mg/kg, i.g.) and three doses of GCIP-27 (10, 30, 90 μg/kg; i.p., bid), respectively. Heart failure was induced by Dox, which was administered at a 20 mg/kg cumulative dose. After 10 weeks of treatment, we observed that GCIP-27 (30, 90 μg/kg) significantly increased ejection fraction, fraction shortening, stroke volume and sarcoplasmic reticulum Ca2+ ATPase activity of Dox-treated hearts. Additionally, GCIP-27 decreased myocardial injury, heart weight index and left ventricular weight index, fibrosis and serum cardiac troponin-I concentration in Dox-treated mice. Immunohistochemistry, western blotting and real-time PCR experiments indicated that GCIP-27 (10–90 μg/kg) could markedly upregulate the protein expression of myocardial α-myosin heavy chain (MHC), Bcl-2, protein kinase C (PKC) ε and phosphorylated extracellular signal-regulated kinase (p-ERK) 1/2 as well as the mRNA expression of α-MHC, but downregulated the expression of β-MHC, Bax and PKC βII, and the mRNA expression levels of β-MHC in Dox-treated mice. It was also found that GCIP-27 (30, 90 μg/L) decreased cell size and protein content of cardiomyocytes significantly in vitro by comparison of Dox group. Conclusions GCIP-27 could effectively ameliorate heart failure development induced by Dox. PKC–ERK1/2 signaling might represent the underlying mechanism of the beneficial effects of GCIP-27." @default.
- W2018762489 created "2016-06-24" @default.
- W2018762489 creator A5009731807 @default.
- W2018762489 creator A5013697180 @default.
- W2018762489 creator A5023579119 @default.
- W2018762489 creator A5041152979 @default.
- W2018762489 creator A5067755874 @default.
- W2018762489 creator A5073026158 @default.
- W2018762489 creator A5079389777 @default.
- W2018762489 creator A5089611409 @default.
- W2018762489 date "2015-03-30" @default.
- W2018762489 modified "2023-10-16" @default.
- W2018762489 title "Gαq Protein Carboxyl Terminus Imitation Polypeptide GCIP-27 Improves Cardiac Function in Chronic Heart Failure Rats" @default.
- W2018762489 cites W1501021182 @default.
- W2018762489 cites W1548858272 @default.
- W2018762489 cites W1596495551 @default.
- W2018762489 cites W1975043059 @default.
- W2018762489 cites W1975833157 @default.
- W2018762489 cites W1976130440 @default.
- W2018762489 cites W1977510522 @default.
- W2018762489 cites W1983978847 @default.
- W2018762489 cites W1986068964 @default.
- W2018762489 cites W1990267943 @default.
- W2018762489 cites W1991246546 @default.
- W2018762489 cites W1999242870 @default.
- W2018762489 cites W2000537144 @default.
- W2018762489 cites W2002637742 @default.
- W2018762489 cites W2005874282 @default.
- W2018762489 cites W2015799510 @default.
- W2018762489 cites W2020343381 @default.
- W2018762489 cites W2021004847 @default.
- W2018762489 cites W2025404395 @default.
- W2018762489 cites W2026039677 @default.
- W2018762489 cites W2027082110 @default.
- W2018762489 cites W2028297089 @default.
- W2018762489 cites W2036381550 @default.
- W2018762489 cites W2039308637 @default.
- W2018762489 cites W2047216932 @default.
- W2018762489 cites W2049401019 @default.
- W2018762489 cites W2049727461 @default.
- W2018762489 cites W2053995472 @default.
- W2018762489 cites W2054990010 @default.
- W2018762489 cites W2056982291 @default.
- W2018762489 cites W2062304838 @default.
- W2018762489 cites W2083594087 @default.
- W2018762489 cites W2084121801 @default.
- W2018762489 cites W2086203501 @default.
- W2018762489 cites W2095607155 @default.
- W2018762489 cites W2096270722 @default.
- W2018762489 cites W2098602153 @default.
- W2018762489 cites W2102085604 @default.
- W2018762489 cites W2103805355 @default.
- W2018762489 cites W2109712401 @default.
- W2018762489 cites W2113934901 @default.
- W2018762489 cites W2119314695 @default.
- W2018762489 cites W2119994814 @default.
- W2018762489 cites W2122859027 @default.
- W2018762489 cites W2124037698 @default.
- W2018762489 cites W2135178837 @default.
- W2018762489 cites W2147296453 @default.
- W2018762489 cites W2148608806 @default.
- W2018762489 cites W2148910374 @default.
- W2018762489 cites W2153819921 @default.
- W2018762489 cites W2154720198 @default.
- W2018762489 cites W2156232348 @default.
- W2018762489 cites W2157091853 @default.
- W2018762489 cites W2162756907 @default.
- W2018762489 cites W2166132724 @default.
- W2018762489 cites W2166744427 @default.
- W2018762489 cites W2166853284 @default.
- W2018762489 cites W2201778716 @default.
- W2018762489 cites W2316617687 @default.
- W2018762489 cites W2417871288 @default.
- W2018762489 cites W2423147615 @default.
- W2018762489 cites W2475261460 @default.
- W2018762489 cites W4206632929 @default.
- W2018762489 cites W4239969880 @default.
- W2018762489 doi "https://doi.org/10.1371/journal.pone.0121007" @default.
- W2018762489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4379177" @default.
- W2018762489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25822412" @default.
- W2018762489 hasPublicationYear "2015" @default.
- W2018762489 type Work @default.
- W2018762489 sameAs 2018762489 @default.
- W2018762489 citedByCount "4" @default.
- W2018762489 countsByYear W20187624892016 @default.
- W2018762489 countsByYear W20187624892017 @default.
- W2018762489 countsByYear W20187624892020 @default.
- W2018762489 crossrefType "journal-article" @default.
- W2018762489 hasAuthorship W2018762489A5009731807 @default.
- W2018762489 hasAuthorship W2018762489A5013697180 @default.
- W2018762489 hasAuthorship W2018762489A5023579119 @default.
- W2018762489 hasAuthorship W2018762489A5041152979 @default.
- W2018762489 hasAuthorship W2018762489A5067755874 @default.
- W2018762489 hasAuthorship W2018762489A5073026158 @default.
- W2018762489 hasAuthorship W2018762489A5079389777 @default.
- W2018762489 hasAuthorship W2018762489A5089611409 @default.
- W2018762489 hasBestOaLocation W20187624891 @default.
- W2018762489 hasConcept C104317684 @default.