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• W2018762574 abstract "<h3>Objective.</h3> —To study the epidemiology of childhood pneumococcal invasive infections in Israel as a background for immunization programs. <h3>Design.</h3> —A 2-year (October 1988 through September 1990) prospective, nationwide surveillance of all invasive pediatric pneumococcal infections. <h3>Setting.</h3> —All 25 medical centers hospitalizing children in Israel, including all laboratories performing blood cultures from pediatric patients. <h3>Patients.</h3> —Infants and children aged 0 to 12 years visiting the pediatric emergency department or hospitalized in pediatric departments were included if<i>Streptococcus pneumoniae</i>was isolated from blood or cerebrospinal fluid. <h3>Results.</h3> —Four hundred sixty-nine invasive infections were diagnosed. Pneumonia, bacteremia without apparent focus, meningitis, and cellulitis were found in 39%, 37%, 17%, and 3%, respectively. The annual incidence was 42 per 100000 for children younger than 5 years of age (104 per 100000 for those <12 months old). The two most common serotypes were 1 and 5, which are rare in Western Europe and North America. Eight groups comprised 82% of all invasive infections. Extrapolated to a population in which 100 000 live births occur yearly, the total annual hospitalizations for pneumococci infections was calculated to be 1928 days. The overall case-fatality rate was 2.2%, but it was 30% during the first month of life. <h3>Conclusions.</h3> —Pneumococcal invasive infections are common in children in Israel and carry considerable morbidity. (<i>JAMA</i>. 1992;268:3328-3332)" @default.
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• W2018762574 date "1992-12-16" @default.
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• W2018762574 title "Epidemiology of Invasive Childhood Pneumococcal Infections in Israel" @default.
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• W2018762574 doi "https://doi.org/10.1001/jama.1992.03490230058028" @default.
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