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• W2018762903 abstract "Abstract Type I diabetes is primarily induced by an autoimmune process that destroys the pancreatic Beta cells. Genetic and environmental factors interplay to bring about an insulitis. Given that antibodies to GAD are detectable years before type I diabetes develops, there is a potential for treating and preventing the onset of this autoimmune process even before there is an irreversible pancreatic dysfunction. NOD mice animal models for type 1 diabetes have been studied extensively and have contributed to both pathophysiologic insights and treatments (tolerance induction, T-cell based therapies, DC vaccines)." @default.
• W2018762903 created "2016-06-24" @default.
• W2018762903 creator A5028380965 @default.
• W2018762903 date "2013-06-01" @default.
• W2018762903 modified "2023-09-25" @default.
• W2018762903 title "Immunology of type I diabetes: The journey from animal models to human therapeutics" @default.
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• W2018762903 doi "https://doi.org/10.1016/j.apme.2013.05.008" @default.
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