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• W2018764511 abstract "In Brief BACKGROUND: As orexinergic (OXergic) neurons have been reported to mediate emotional changes, benzodiazepines might interact with OXergic neurons. METHODS: We examined the interactions between OXergic neurons and benzodiazepine receptors in orexin-A (100 nM) and K+ (25 mM)-evoked norepinephrine release from rat cerebrocortical slices. RESULTS: Midazolam, diazepam, and flunitrazepam concentration-dependently inhibited both OX-A- and K+-evoked norepinephrine release. The IC50 of midazolam for orexin-A-evoked release (0.87 μM, P < 0.01), which was insensitive to flumazenil, was significantly lower than that of diazepam and flunitrazepam (around 60 μM), whereas the IC50s for K+-evoked release were not different among the benzodiazepines. CONCLUSION: There may be no interaction between OXergic neurons and central benzodiazepine receptors. IMPLICATIONS: Orexinergic neurons may mediate emotional changes, and benzodiazepines produces anxiolytic effects. However, the present study suggests that there is no interaction between orexinergic neurons and benzodiazepine receptors in the cerebral cortex, although clinically relevant concentrations of midazolam significantly inhibited orexin-evoked norepinephrine release that could not be antagonized by flumazenil." @default.
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• W2018764511 date "2007-02-01" @default.
• W2018764511 modified "2023-10-16" @default.
• W2018764511 title "The Effects of Benzodiazepines on Orexinergic Systems in Rat Cerebrocortical Slices" @default.
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• W2018764511 doi "https://doi.org/10.1213/01.ane.0000252413.62821.2e" @default.
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