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- W2018769377 abstract "The objectives of our studies have been to test the hypothesis that polyhalogenated biphenyls and related chemicals (PHB) can induce cytochrome P450 dependent mixed function monooxygenase family I enzymes (P450I) in the human, and the degree that a PHB induces P450I activity in the human correlates to the toxicity of the chemical. The P450I family enzyme, P450IA2, activity was monitored in the human by the caffeine breath test. The study subjects were exposed to high amounts of polybrominated biphenyls (PBB), polychlorinated biphenyls with polychlorinated dibenzofurans (PCB/DFs), or mirex. All the PHBs induced the P450IA2 activity of the exposed subjects as compared to the nonexposed control group. The capacity of each PHB to induce P450IA2 activity correlated with the known toxicity of each exposure (PCBDFPBB >mirex) in the human. P450IA2 activity as measured by the caffeine breath test may by a most useful biomarker in monitoring and understanding the effects of PHBs on the human population." @default.
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- W2018769377 date "1992-07-01" @default.
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- W2018769377 title "Cytochrome P450IA2 in vivo induction: A potential biomarker of polyhalogenated biphenyls and their related chemical's effects on the human" @default.
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