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- W2018771027 abstract "We have previously reported methods that allow for the routine isolation, culture and transplantation of multipotent neural progenitor cells (NPCs) derived from the adult rat sub-ventricular zone (SVZ). In order to expand these techniques, the aim of the current study was to develop an in vitro strategy which can prime proliferating adult NPCs towards a neuronal fate during their subsequent differentiation under standard conditions. Our results show that transient exposure to lithium chloride during in vitro proliferation of adult SVZ-derived NPCs has the ability to alter differential fate in vitro and increase the proportion of cells expressing neuronal markers while at the same time causing a reduction in glial progeny. Treatment of adult NPCs with lithium chloride may therefore provide a novel mechanism by which adult NPCs can be primed towards a specific neuronal fate for cell replacement therapy." @default.
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- W2018771027 date "2009-04-01" @default.
- W2018771027 modified "2023-10-18" @default.
- W2018771027 title "In vitro priming to direct neuronal fate in adult neural progenitor cells" @default.
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- W2018771027 doi "https://doi.org/10.1016/j.expneurol.2008.12.023" @default.
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