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- W2018773179 abstract "Conventional chemotherapeutic drugs do not selectively localize to tumors, causing undesired toxicities to healthy organs, and precluding the escalation to therapeutically active regimens. The selective delivery at sites of disease of potent effector molecules represents a promising strategy for the treatment of cancer and other diseases. High affinity antibodies towards disease-associated antigens are currently the vehicles of choice for the targeted delivery of payloads. Low molecular weight ligands have the potential to overcome some of the intrinsic limitations associated with antibodies, and have recently been proposed for the development of a novel class of targeted therapeutics. However, the identification of binding molecules, which display high affinity properties and exquisite specificity against protein of therapeutic interest, remains a great challenge. DNA-encoded chemical library technology relies on small molecule libraries of unprecedented size to identify high affinity ligands towards specific target proteins, and could help in the development of next generation targeted cytotoxics." @default.
- W2018773179 created "2016-06-24" @default.
- W2018773179 creator A5029698383 @default.
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- W2018773179 date "2015-06-01" @default.
- W2018773179 modified "2023-09-25" @default.
- W2018773179 title "Small targeted cytotoxics from DNA-encoded chemical libraries" @default.
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- W2018773179 doi "https://doi.org/10.1016/j.cbpa.2015.02.009" @default.
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