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- W2018775332 abstract "Paiement, J.-P., Prichard, R. K., and Ribeiro, P. 1999.Haemonchus contortus: Characterization of a glutamate binding site in unselected and Ivermectin-selected larvae and adults.Experimental Parasitology92,32–39. A specific ivermectin-sensitive, glutamate binding site has been identified in the parasitic nematodeHaemonchus contortus. Glutamate binding inH. contortuswas saturable and occurred in a single class of high-affinity binding sites which appeared to have pharmacological properties different from those of mammalian glutamate receptors. Adult and larval forms ofH. contortushad dramatically different glutamate binding kinetics, the larvae showing nearly up to 200-fold higher Bmaxvalues and up to 9-fold increases in Kdvalues compared to adults. Treatment of adultH. contortuswith the anthelmintic, ivermectin, decreased the Bmaxvalue for glutamate binding in the susceptible strain but not in the resistant parasites. Furthermore, selection for ivermectin resistance was associated with a significant increase in Bmaxfor glutamate binding in adults and a similarly significant increase in glutamate binding affinity in larvae. These results suggest that theH. contortusglutamate binding site identified in this study may be involved in the phenomenon of ivermectin resistance." @default.
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- W2018775332 date "1999-05-01" @default.
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- W2018775332 title "Haemonchus contortus:Characterization of a Glutamate Binding Site in Unselected and Ivermectin-Selected Larvae and Adults" @default.
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- W2018775332 doi "https://doi.org/10.1006/expr.1999.4396" @default.
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