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- W2018776505 abstract "A study of the effects of low concentrations of calcium on the polyphosphoinositides and phosphatidate of normal human erythrocytes, in the presence of ionophore A23187, was carried out. The metabolism of these phospholipids in pathologic erythrocytes (sickle cells and pyropoikilocytes) that are leaky to calcium was also investigated. In erythrocyte polyphosphoinositides prelabelled with 32Pi, decreases of 40 and 70% in the radioactivity associated with triphosphoinositide were observed in media containing 10 and 100 μM CaCl2, respectively, in the presence of the ionophore, as compared to controls. Diphosphoinositide was comparatively less sensitive to calcium-induced breakdown. Incorporation of 32Pi into phosphatidate increased as the concentration of calcium in the medium increased. When isolated erythrocyte membranes pre-labelled with 32Pi were exposed to calcium, a marked loss of radioactivity associated with polyphosphoinositides was observed in medium containing 100 μM CaCl2. However, radioactivity associated with phosphatidate showed little change under the above conditions. The general pattern of incorporation of 32Pi (2 : 1 : 1 into triphosphoinositide : diphosphoinositide : phosphatidate) into normal erythrocytes was altered in pathological erythrocytes (sickle cells and hereditary pyropoikilocytes), with a higher incorporation of 32Pi into diphosphoinositide or phosphatidate or both. Re-incubation of 32Pi pre-labelled erythrocytes with 1 · 10−7 to 1 · 10−5 M carbamylcholine had no effect on the polyphosphoinositides or phosphatidate metabolism." @default.
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- W2018776505 title "Calcium-induced changes in polyphosphoinositides and phosphatidate in normal erythrocytes, sickle cells and hereditary pyropoikilocytes" @default.
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- W2018776505 doi "https://doi.org/10.1016/0005-2736(80)90030-9" @default.
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