FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018776986> ?p ?o ?g. }

• W2018776986 endingPage "4712" @default.
• W2018776986 startingPage "4705" @default.
• W2018776986 abstract "It has previously been shown that the E7 protein from the cutaneous human papillomavirus type 1 (HPV1), which is associated with benign skin lesions, binds the product of the tumor suppressor gene retinoblastoma (pRb) with an efficiency similar to that of the E7 protein from the oncogenic HPV type 16. Despite this ability, HPV1 E7 does not display any activity in transforming primary cells. In addition, the two viral proteins differ in their mechanisms of targeting pRb. HPV16 E7 promotes pRb destabilization, while cells expressing HPV1 E7 do not show any decrease in pRb levels. In this study, we show that HPV1 E7, in contrast to HPV16 E7, has only a weak activity to neutralize the effect of cyclin-dependent kinase inhibitor p16INK4a. By generation of HPV1/16 E7 chimeric proteins, we have identified a central motif in the two E7 proteins, which determines their different abilities to overcome the p16INK4a-mediated cell cycle arrest. This motif is located downstream of the pRb-binding domain and comprises only three amino acids in HPV16 E7. Swapping this central motif in the two viral proteins causes an exchange of their activities involved in circumventing the inhibitory function of p16INK4a. Most importantly, our data show that the efficiency of the E7 proteins in neutralizing the inhibitory effect of p16INK4a correlates with their ability to promote pRb degradation." @default.
• W2018776986 created "2016-06-24" @default.
• W2018776986 creator A5015156425 @default.
• W2018776986 creator A5033958281 @default.
• W2018776986 creator A5049004548 @default.
• W2018776986 creator A5059805941 @default.
• W2018776986 creator A5060776127 @default.
• W2018776986 creator A5077471028 @default.
• W2018776986 date "2001-05-15" @default.
• W2018776986 modified "2023-10-18" @default.
• W2018776986 title "Induction of pRb Degradation by the Human Papillomavirus Type 16 E7 Protein Is Essential To Efficiently Overcome p16 ^INK4a -Imposed G ₁ Cell Cycle Arrest" @default.
• W2018776986 cites W10480338 @default.
• W2018776986 cites W1481295510 @default.
• W2018776986 cites W1540314522 @default.
• W2018776986 cites W1557998194 @default.
• W2018776986 cites W1675517407 @default.
• W2018776986 cites W190015672 @default.
• W2018776986 cites W1975549269 @default.
• W2018776986 cites W1976220823 @default.
• W2018776986 cites W1980316863 @default.
• W2018776986 cites W2006659499 @default.
• W2018776986 cites W2010493387 @default.
• W2018776986 cites W2013884760 @default.
• W2018776986 cites W2024073334 @default.
• W2018776986 cites W2031841054 @default.
• W2018776986 cites W2035066068 @default.
• W2018776986 cites W2038500217 @default.
• W2018776986 cites W2059285636 @default.
• W2018776986 cites W2078912202 @default.
• W2018776986 cites W2087404852 @default.
• W2018776986 cites W2094171232 @default.
• W2018776986 cites W2107030711 @default.
• W2018776986 cites W2121619780 @default.
• W2018776986 cites W2138461309 @default.
• W2018776986 cites W2141136534 @default.
• W2018776986 cites W2143019738 @default.
• W2018776986 cites W2313043060 @default.
• W2018776986 cites W4237567990 @default.
• W2018776986 cites W714337 @default.
• W2018776986 doi "https://doi.org/10.1128/jvi.75.10.4705-4712.2001" @default.
• W2018776986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/114225" @default.
• W2018776986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11312342" @default.
• W2018776986 hasPublicationYear "2001" @default.
• W2018776986 type Work @default.
• W2018776986 sameAs 2018776986 @default.
• W2018776986 citedByCount "134" @default.
• W2018776986 countsByYear W20187769862012 @default.
• W2018776986 countsByYear W20187769862013 @default.
• W2018776986 countsByYear W20187769862014 @default.
• W2018776986 countsByYear W20187769862015 @default.
• W2018776986 countsByYear W20187769862016 @default.
• W2018776986 countsByYear W20187769862017 @default.
• W2018776986 countsByYear W20187769862018 @default.
• W2018776986 countsByYear W20187769862019 @default.
• W2018776986 countsByYear W20187769862020 @default.
• W2018776986 countsByYear W20187769862021 @default.
• W2018776986 countsByYear W20187769862022 @default.
• W2018776986 countsByYear W20187769862023 @default.
• W2018776986 crossrefType "journal-article" @default.
• W2018776986 hasAuthorship W2018776986A5015156425 @default.
• W2018776986 hasAuthorship W2018776986A5033958281 @default.
• W2018776986 hasAuthorship W2018776986A5049004548 @default.
• W2018776986 hasAuthorship W2018776986A5059805941 @default.
• W2018776986 hasAuthorship W2018776986A5060776127 @default.
• W2018776986 hasAuthorship W2018776986A5077471028 @default.
• W2018776986 hasBestOaLocation W20187769861 @default.
• W2018776986 hasConcept C104317684 @default.
• W2018776986 hasConcept C105696609 @default.
• W2018776986 hasConcept C153911025 @default.
• W2018776986 hasConcept C179185449 @default.
• W2018776986 hasConcept C199835354 @default.
• W2018776986 hasConcept C2776062698 @default.
• W2018776986 hasConcept C2911011838 @default.
• W2018776986 hasConcept C29537977 @default.
• W2018776986 hasConcept C502942594 @default.
• W2018776986 hasConcept C54355233 @default.
• W2018776986 hasConcept C83258922 @default.
• W2018776986 hasConcept C86803240 @default.
• W2018776986 hasConcept C95444343 @default.
• W2018776986 hasConceptScore W2018776986C104317684 @default.
• W2018776986 hasConceptScore W2018776986C105696609 @default.
• W2018776986 hasConceptScore W2018776986C153911025 @default.
• W2018776986 hasConceptScore W2018776986C179185449 @default.
• W2018776986 hasConceptScore W2018776986C199835354 @default.
• W2018776986 hasConceptScore W2018776986C2776062698 @default.
• W2018776986 hasConceptScore W2018776986C2911011838 @default.
• W2018776986 hasConceptScore W2018776986C29537977 @default.
• W2018776986 hasConceptScore W2018776986C502942594 @default.
• W2018776986 hasConceptScore W2018776986C54355233 @default.
• W2018776986 hasConceptScore W2018776986C83258922 @default.
• W2018776986 hasConceptScore W2018776986C86803240 @default.
• W2018776986 hasConceptScore W2018776986C95444343 @default.
• W2018776986 hasIssue "10" @default.
• W2018776986 hasLocation W20187769861 @default.
• W2018776986 hasLocation W20187769862 @default.
• W2018776986 hasLocation W20187769863 @default.
• W2018776986 hasLocation W20187769864 @default.
• W2018776986 hasOpenAccess W2018776986 @default.

• next