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• W2018782357 abstract "The release of amyloid-β peptide (Aβ) from β-amyloid precursor protein (APP) requires cleavage by β- and γ-secretases. Several groups have identified a candidate for the β-site APP-cleaving enzyme, BACE1, and its homologue BACE2. We sequenced the genes for BACE1 and BACE2 and found several polymorphisms in both genes. Genotyping a large cohort of AD cases and controls has shown no association between AD and the intronic polymorphism in BACE2 while there was a weak association between the BACE1 polymorphism in exon 5 and AD in those carrying the APOE ∊4 allele." @default.
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• W2018782357 date "2001-07-01" @default.
• W2018782357 modified "2023-10-18" @default.
• W2018782357 title "Association studies using novel polymorphisms in BACE1 and BACE2" @default.
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• W2018782357 doi "https://doi.org/10.1097/00001756-200107030-00008" @default.
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