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- W2018784413 abstract "The distribution of CD3+ T lymphocytes and the expression of interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor α (TNFα) by macrophages in canine lymph nodes with mineral-associated lymphadenopathy, granulomatous lymphadenitis or reactive hyperplasia was examined immunohistochemically. In areas of preserved lymph node architecture, CD3+ T lymphocytes were located in the paracortex, with scattered cells in the follicular mantle and germinal centre, and small aggregates in the medullary cords. T cells were prominent within areas of diffuse granulomatous inflammation and formed a peripheral rim around microgranulomas. TNFα expression was demonstrated in macrophages from seven of 11 dogs with mineral-associated lymphadenopathy, one of five dogs with granulomatous lymphadenitis and three of five with reactive hyperplasia. Positive macrophage staining for IL-1β and IL-6 was seen in two lymph nodes with reactive hyperplasia. Lymph nodes from control (clinically normal) dogs showed no evidence of cytokine expression. Neutrophils expressing IL-1β were observed within the medullary sinuses of two lymph nodes with mineral-associated lymphadenopathy and one with reactive hyperplasia, and in the inflammatory infiltrate in one lymph node with granulomatous lymphadenitis. The sensitivity of immunohistochemical examination as a means of detecting cytokines in abnormal tissue is discussed." @default.
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- W2018784413 title "Expression of interleukin-1β, interleukin-6 and tumour necrosis factor α by macrophages in canine lymph nodes with mineral-associated lymphadenopathy, granulomatous lymphadenitis or reactive hyperplasia" @default.
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- W2018784413 doi "https://doi.org/10.1016/s0021-9975(96)80060-0" @default.
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