FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018785320> ?p ?o ?g. }

• W2018785320 endingPage "1053" @default.
• W2018785320 startingPage "1043" @default.
• W2018785320 abstract "We studied the effects of PNU-109 291 [(S)-(−)-1-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-N-methyl-isochroman-6-carboxamide], a receptor agonist showing 5000-fold selectivity for primate 5-HT1D versus 5-HT1B receptors (Ennis et al., J. Med. Chem. 41, 2180–2183), on dural neurogenic inflammation and on c-fos like immunoreactivity within trigeminal nucleus caudalis evoked by electrical and chemical activation of trigeminal afferents, respectively. Subcutaneous injection of PNU-109 291 in male guinea pigs dose-dependently reduced dural extravasation of [125I]-labeled bovine serum albumin evoked by trigeminal ganglion stimulation with an IC50 of 4.2 nmol kg−1. A dose of 73.3 nmol kg−1 blocked the response completely. The selective 5-HT1B/1D receptor antagonist GR-127 935 (≥2 μmol kg−1 i.v.) prevented this effect. In addition, the number of c-fos immunoreactive cells within guinea pig trigeminal nucleus caudalis induced by chemical meningeal stimulation (intracisternally administered capsaicin) was reduced by more than 50% with PNU-109 291 (≥122.2 nmol kg−1 administered s.c. 45 min before and 15 min after capsaicin). These data indicate that the 5-HT1D receptor subtype plays a significant role in suppressing meningeal neurogenic inflammation and attenuating trigeminal nociception in these guinea pig models. Since 5-HT1D receptor mRNA and protein are expressed in trigeminal ganglia but not vascular smooth muscle, the 5-HT1D receptor subtype may become a useful therapeutic target for migraine and related headaches." @default.
• W2018785320 created "2016-06-24" @default.
• W2018785320 creator A5041862639 @default.
• W2018785320 creator A5042591460 @default.
• W2018785320 creator A5061147729 @default.
• W2018785320 creator A5075636467 @default.
• W2018785320 creator A5078007632 @default.
• W2018785320 date "1999-07-01" @default.
• W2018785320 modified "2023-10-15" @default.
• W2018785320 title "Effects of PNU-109,291, a selective 5-HT1D receptor agonist, on electrically induced dural plasma extravasation and capsaicin-evoked c-fos immunoreactivity within trigeminal nucleus caudalis" @default.
• W2018785320 cites W111403972 @default.
• W2018785320 cites W1771060587 @default.
• W2018785320 cites W1964030516 @default.
• W2018785320 cites W1968081766 @default.
• W2018785320 cites W1974192591 @default.
• W2018785320 cites W1975452171 @default.
• W2018785320 cites W1976782762 @default.
• W2018785320 cites W1980572546 @default.
• W2018785320 cites W1983962867 @default.
• W2018785320 cites W1984868484 @default.
• W2018785320 cites W1990951914 @default.
• W2018785320 cites W1993802939 @default.
• W2018785320 cites W1995838863 @default.
• W2018785320 cites W2000218690 @default.
• W2018785320 cites W2004492247 @default.
• W2018785320 cites W2006151920 @default.
• W2018785320 cites W2007963779 @default.
• W2018785320 cites W2016513895 @default.
• W2018785320 cites W2017208290 @default.
• W2018785320 cites W2017863853 @default.
• W2018785320 cites W2018088414 @default.
• W2018785320 cites W2024258521 @default.
• W2018785320 cites W2042217422 @default.
• W2018785320 cites W2048890514 @default.
• W2018785320 cites W2049691147 @default.
• W2018785320 cites W2057335558 @default.
• W2018785320 cites W2058210433 @default.
• W2018785320 cites W2058424007 @default.
• W2018785320 cites W2062761297 @default.
• W2018785320 cites W2065223010 @default.
• W2018785320 cites W2065826282 @default.
• W2018785320 cites W2066457807 @default.
• W2018785320 cites W2067546725 @default.
• W2018785320 cites W2068699996 @default.
• W2018785320 cites W2069735942 @default.
• W2018785320 cites W2070635558 @default.
• W2018785320 cites W2074631079 @default.
• W2018785320 cites W2076634042 @default.
• W2018785320 cites W2077810415 @default.
• W2018785320 cites W2079316276 @default.
• W2018785320 cites W2085796321 @default.
• W2018785320 cites W2106164636 @default.
• W2018785320 cites W2108454195 @default.
• W2018785320 cites W2119573080 @default.
• W2018785320 cites W2164703847 @default.
• W2018785320 cites W2164938770 @default.
• W2018785320 cites W2312806913 @default.
• W2018785320 cites W2329775224 @default.
• W2018785320 doi "https://doi.org/10.1016/s0028-3908(99)00032-5" @default.
• W2018785320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10428423" @default.
• W2018785320 hasPublicationYear "1999" @default.
• W2018785320 type Work @default.
• W2018785320 sameAs 2018785320 @default.
• W2018785320 citedByCount "46" @default.
• W2018785320 countsByYear W20187853202012 @default.
• W2018785320 countsByYear W20187853202013 @default.
• W2018785320 countsByYear W20187853202014 @default.
• W2018785320 countsByYear W20187853202015 @default.
• W2018785320 countsByYear W20187853202016 @default.
• W2018785320 countsByYear W20187853202017 @default.
• W2018785320 countsByYear W20187853202018 @default.
• W2018785320 countsByYear W20187853202019 @default.
• W2018785320 countsByYear W20187853202020 @default.
• W2018785320 countsByYear W20187853202021 @default.
• W2018785320 countsByYear W20187853202022 @default.
• W2018785320 countsByYear W20187853202023 @default.
• W2018785320 crossrefType "journal-article" @default.
• W2018785320 hasAuthorship W2018785320A5041862639 @default.
• W2018785320 hasAuthorship W2018785320A5042591460 @default.
• W2018785320 hasAuthorship W2018785320A5061147729 @default.
• W2018785320 hasAuthorship W2018785320A5075636467 @default.
• W2018785320 hasAuthorship W2018785320A5078007632 @default.
• W2018785320 hasConcept C126322002 @default.
• W2018785320 hasConcept C134018914 @default.
• W2018785320 hasConcept C142724271 @default.
• W2018785320 hasConcept C15490471 @default.
• W2018785320 hasConcept C169760540 @default.
• W2018785320 hasConcept C170493617 @default.
• W2018785320 hasConcept C185592680 @default.
• W2018785320 hasConcept C24998067 @default.
• W2018785320 hasConcept C2776352249 @default.
• W2018785320 hasConcept C2776700747 @default.
• W2018785320 hasConcept C2778938600 @default.
• W2018785320 hasConcept C2779540182 @default.
• W2018785320 hasConcept C2780051329 @default.
• W2018785320 hasConcept C71924100 @default.
• W2018785320 hasConcept C86803240 @default.
• W2018785320 hasConcept C94487597 @default.

• next