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- W2018792466 endingPage "3948" @default.
- W2018792466 startingPage "3939" @default.
- W2018792466 abstract "Summary Polycomb group (PcG) genes encode chromatin modifiers that are involved in the maintenance of cell identity and in proliferation, processes that are often deregulated in cancer. Interestingly, besides a role in epigenetic gene silencing, recent studies have begun to uncover a function for PcG proteins in the cellular response to DNA damage. In particular, PcG proteins have been shown to accumulate at sites of DNA double-strand breaks (DSBs). Several signaling pathways contribute to the recruitment of PcG proteins to DSBs, where they catalyze the ubiquitylation of histone H2A. The relevance of these findings is supported by the fact that loss of PcG genes decreases the efficiency of cells to repair DSBs and renders them sensitive to ionizing radiation. The recruitment of PcG proteins to DNA breaks suggests that they have a function in coordinating gene silencing and DNA repair at the chromatin flanking DNA lesions. In this Commentary, we discuss the current knowledge of the mechanisms that allow PcG proteins to exert their positive functions in genome maintenance." @default.
- W2018792466 created "2016-06-24" @default.
- W2018792466 creator A5037844441 @default.
- W2018792466 creator A5041770236 @default.
- W2018792466 creator A5063380198 @default.
- W2018792466 date "2012-09-01" @default.
- W2018792466 modified "2023-10-01" @default.
- W2018792466 title "The emerging role of Polycomb repressors in the response to DNA damage" @default.
- W2018792466 cites W1481473039 @default.
- W2018792466 cites W1538419182 @default.
- W2018792466 cites W1845461494 @default.
- W2018792466 cites W1933538082 @default.
- W2018792466 cites W1966383291 @default.
- W2018792466 cites W1967269362 @default.
- W2018792466 cites W1968870521 @default.
- W2018792466 cites W1970018249 @default.
- W2018792466 cites W1970266671 @default.
- W2018792466 cites W1973030224 @default.
- W2018792466 cites W1973279069 @default.
- W2018792466 cites W1973904343 @default.
- W2018792466 cites W1974755980 @default.
- W2018792466 cites W1975702835 @default.
- W2018792466 cites W1977836335 @default.
- W2018792466 cites W1978282378 @default.
- W2018792466 cites W1978780879 @default.
- W2018792466 cites W1981525849 @default.
- W2018792466 cites W1982602899 @default.
- W2018792466 cites W1984948591 @default.
- W2018792466 cites W1986302429 @default.
- W2018792466 cites W1989800108 @default.
- W2018792466 cites W1995652309 @default.
- W2018792466 cites W1996947994 @default.
- W2018792466 cites W1998129814 @default.
- W2018792466 cites W1998499862 @default.
- W2018792466 cites W2000491188 @default.
- W2018792466 cites W2001029086 @default.
- W2018792466 cites W2001499126 @default.
- W2018792466 cites W2008185037 @default.
- W2018792466 cites W2008396969 @default.
- W2018792466 cites W2008686279 @default.
- W2018792466 cites W2010941702 @default.
- W2018792466 cites W2012598468 @default.
- W2018792466 cites W2015132841 @default.
- W2018792466 cites W2016581702 @default.
- W2018792466 cites W2021044341 @default.
- W2018792466 cites W2021565943 @default.
- W2018792466 cites W2023050187 @default.
- W2018792466 cites W2025553576 @default.
- W2018792466 cites W2028003321 @default.
- W2018792466 cites W2028224002 @default.
- W2018792466 cites W2030246401 @default.
- W2018792466 cites W2032739040 @default.
- W2018792466 cites W2033890667 @default.
- W2018792466 cites W2035488182 @default.
- W2018792466 cites W2038204769 @default.
- W2018792466 cites W2038949557 @default.
- W2018792466 cites W2039143648 @default.
- W2018792466 cites W2041656651 @default.
- W2018792466 cites W2044868606 @default.
- W2018792466 cites W2046329243 @default.
- W2018792466 cites W2048916800 @default.
- W2018792466 cites W2050646440 @default.
- W2018792466 cites W2054782539 @default.
- W2018792466 cites W2055148721 @default.
- W2018792466 cites W2055361823 @default.
- W2018792466 cites W2057586248 @default.
- W2018792466 cites W2058471321 @default.
- W2018792466 cites W2059365987 @default.
- W2018792466 cites W2060608189 @default.
- W2018792466 cites W2060870400 @default.
- W2018792466 cites W2061462200 @default.
- W2018792466 cites W2064871244 @default.
- W2018792466 cites W2065055008 @default.
- W2018792466 cites W2066865996 @default.
- W2018792466 cites W2068973408 @default.
- W2018792466 cites W2070604452 @default.
- W2018792466 cites W2072150230 @default.
- W2018792466 cites W2075087486 @default.
- W2018792466 cites W2075808226 @default.
- W2018792466 cites W2077436902 @default.
- W2018792466 cites W2078115314 @default.
- W2018792466 cites W2078544177 @default.
- W2018792466 cites W2082959814 @default.
- W2018792466 cites W2083654253 @default.
- W2018792466 cites W2085178889 @default.
- W2018792466 cites W2086486581 @default.
- W2018792466 cites W2089827566 @default.
- W2018792466 cites W2091073356 @default.
- W2018792466 cites W2092761963 @default.
- W2018792466 cites W2095002834 @default.
- W2018792466 cites W2097451573 @default.
- W2018792466 cites W2101139969 @default.
- W2018792466 cites W2106059513 @default.
- W2018792466 cites W2108196925 @default.
- W2018792466 cites W2114860131 @default.
- W2018792466 cites W2114982790 @default.
- W2018792466 cites W2116565356 @default.
- W2018792466 cites W2118225942 @default.