FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018793707> ?p ?o ?g. }

• W2018793707 endingPage "1060" @default.
• W2018793707 startingPage "1052" @default.
• W2018793707 abstract "Clostridium difficile infections (CDIs) are the leading cause of hospital-acquired infectious diarrhea and primarily involve two exotoxins, TcdA and TcdB. Actoxumab and bezlotoxumab are human monoclonal antibodies that neutralize the cytotoxic/cytopathic effects of TcdA and TcdB, respectively. In a phase II clinical study, the actoxumab-bezlotoxumab combination reduced the rate of CDI recurrence in patients who were also treated with standard-of-care antibiotics. However, it is not known whether the antibody combination will be effective against a broad range of C. difficile strains. As a first step toward addressing this, we tested the ability of actoxumab and bezlotoxumab to neutralize the activities of toxins from a number of clinically relevant and geographically diverse strains of C. difficile. Neutralization potencies, as measured in a cell growth/survival assay with purified toxins from various C. difficile strains, correlated well with antibody/toxin binding affinities. Actoxumab and bezlotoxumab neutralized toxins from culture supernatants of all clinical isolates tested, including multiple isolates of the BI/NAP1/027 and BK/NAP7/078 strains, at antibody concentrations well below plasma levels observed in humans. We compared the bezlotoxumab epitopes in the TcdB receptor binding domain across known TcdB sequences and found that key substitutions within the bezlotoxumab epitopes correlated with the relative differences in potencies of bezlotoxumab against TcdB of some strains, including ribotypes 027 and 078. Combined with in vitro neutralization data, epitope modeling will enhance our ability to predict the coverage of new and emerging strains by actoxumab-bezlotoxumab in the clinic." @default.
• W2018793707 created "2016-06-24" @default.
• W2018793707 creator A5000218387 @default.
• W2018793707 creator A5017187552 @default.
• W2018793707 creator A5026775376 @default.
• W2018793707 creator A5035358542 @default.
• W2018793707 creator A5066771307 @default.
• W2018793707 creator A5069314560 @default.
• W2018793707 creator A5076521215 @default.
• W2018793707 creator A5091380652 @default.
• W2018793707 date "2015-02-01" @default.
• W2018793707 modified "2023-10-13" @default.
• W2018793707 title "Broad Coverage of Genetically Diverse Strains of Clostridium difficile by Actoxumab and Bezlotoxumab Predicted by <i>In Vitro</i> Neutralization and Epitope Modeling" @default.
• W2018793707 cites W1968953113 @default.
• W2018793707 cites W1969569614 @default.
• W2018793707 cites W2012852554 @default.
• W2018793707 cites W2049355215 @default.
• W2018793707 cites W2072832624 @default.
• W2018793707 cites W2078443771 @default.
• W2018793707 cites W2097330653 @default.
• W2018793707 cites W2099116375 @default.
• W2018793707 cites W2101233913 @default.
• W2018793707 cites W2106938218 @default.
• W2018793707 cites W2108975442 @default.
• W2018793707 cites W2109689528 @default.
• W2018793707 cites W2110384819 @default.
• W2018793707 cites W2115999384 @default.
• W2018793707 cites W2119576620 @default.
• W2018793707 cites W2122576306 @default.
• W2018793707 cites W2123146097 @default.
• W2018793707 cites W2128815614 @default.
• W2018793707 cites W2144370711 @default.
• W2018793707 cites W2144509456 @default.
• W2018793707 cites W2148404862 @default.
• W2018793707 cites W2167368902 @default.
• W2018793707 cites W2333302180 @default.
• W2018793707 doi "https://doi.org/10.1128/aac.04433-14" @default.
• W2018793707 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4335902" @default.
• W2018793707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25451052" @default.
• W2018793707 hasPublicationYear "2015" @default.
• W2018793707 type Work @default.
• W2018793707 sameAs 2018793707 @default.
• W2018793707 citedByCount "42" @default.
• W2018793707 countsByYear W20187937072015 @default.
• W2018793707 countsByYear W20187937072016 @default.
• W2018793707 countsByYear W20187937072017 @default.
• W2018793707 countsByYear W20187937072018 @default.
• W2018793707 countsByYear W20187937072019 @default.
• W2018793707 countsByYear W20187937072020 @default.
• W2018793707 countsByYear W20187937072021 @default.
• W2018793707 countsByYear W20187937072022 @default.
• W2018793707 countsByYear W20187937072023 @default.
• W2018793707 crossrefType "journal-article" @default.
• W2018793707 hasAuthorship W2018793707A5000218387 @default.
• W2018793707 hasAuthorship W2018793707A5017187552 @default.
• W2018793707 hasAuthorship W2018793707A5026775376 @default.
• W2018793707 hasAuthorship W2018793707A5035358542 @default.
• W2018793707 hasAuthorship W2018793707A5066771307 @default.
• W2018793707 hasAuthorship W2018793707A5069314560 @default.
• W2018793707 hasAuthorship W2018793707A5076521215 @default.
• W2018793707 hasAuthorship W2018793707A5091380652 @default.
• W2018793707 hasBestOaLocation W20187937071 @default.
• W2018793707 hasConcept C134193097 @default.
• W2018793707 hasConcept C14086860 @default.
• W2018793707 hasConcept C159047783 @default.
• W2018793707 hasConcept C159654299 @default.
• W2018793707 hasConcept C185592680 @default.
• W2018793707 hasConcept C195616568 @default.
• W2018793707 hasConcept C202751555 @default.
• W2018793707 hasConcept C203014093 @default.
• W2018793707 hasConcept C2777367657 @default.
• W2018793707 hasConcept C2781092032 @default.
• W2018793707 hasConcept C2994496256 @default.
• W2018793707 hasConcept C501593827 @default.
• W2018793707 hasConcept C523546767 @default.
• W2018793707 hasConcept C542903549 @default.
• W2018793707 hasConcept C54355233 @default.
• W2018793707 hasConcept C55493867 @default.
• W2018793707 hasConcept C86803240 @default.
• W2018793707 hasConcept C89423630 @default.
• W2018793707 hasConcept C97505648 @default.
• W2018793707 hasConceptScore W2018793707C134193097 @default.
• W2018793707 hasConceptScore W2018793707C14086860 @default.
• W2018793707 hasConceptScore W2018793707C159047783 @default.
• W2018793707 hasConceptScore W2018793707C159654299 @default.
• W2018793707 hasConceptScore W2018793707C185592680 @default.
• W2018793707 hasConceptScore W2018793707C195616568 @default.
• W2018793707 hasConceptScore W2018793707C202751555 @default.
• W2018793707 hasConceptScore W2018793707C203014093 @default.
• W2018793707 hasConceptScore W2018793707C2777367657 @default.
• W2018793707 hasConceptScore W2018793707C2781092032 @default.
• W2018793707 hasConceptScore W2018793707C2994496256 @default.
• W2018793707 hasConceptScore W2018793707C501593827 @default.
• W2018793707 hasConceptScore W2018793707C523546767 @default.
• W2018793707 hasConceptScore W2018793707C542903549 @default.
• W2018793707 hasConceptScore W2018793707C54355233 @default.
• W2018793707 hasConceptScore W2018793707C55493867 @default.
• W2018793707 hasConceptScore W2018793707C86803240 @default.

• next