Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018798499> ?p ?o ?g. }
- W2018798499 endingPage "2317" @default.
- W2018798499 startingPage "2307" @default.
- W2018798499 abstract "Abstract Platelet‐derived growth factor receptor alpha ( Pdgfr α) identifies cardiac progenitor cells in the posterior part of the second heart field. We aim to elucidate the role of Pdgfr α in this region. Hearts of Pdgfr α‐deficient mouse embryos (E9.5–E14.5) showed cardiac malformations consisting of atrial and sinus venosus myocardium hypoplasia, including venous valves and sinoatrial node. In vivo staining for Nkx2.5 showed increased myocardial expression in Pdgfr α mutants, confirmed by Western blot analysis. Due to hypoplasia of the primary atrial septum, mesenchymal cap, and dorsal mesenchymal protrusion, the atrioventricular septal complex failed to fuse. Impaired epicardial development and severe blebbing coincided with diminished migration of epicardium‐derived cells and myocardial thinning, which could be linked to increased WT1 and altered α4‐integrin expression. Our data provide novel insight for a possible role for Pdgfr α in transduction pathways that lead to repression of Nkx2.5 and WT1 during development of posterior heart field–derived cardiac structures. Developmental Dynamics 239:2307–2317, 2010. © 2010 Wiley‐Liss, Inc." @default.
- W2018798499 created "2016-06-24" @default.
- W2018798499 creator A5014377544 @default.
- W2018798499 creator A5015411763 @default.
- W2018798499 creator A5030802852 @default.
- W2018798499 creator A5036060072 @default.
- W2018798499 creator A5038268390 @default.
- W2018798499 creator A5050395195 @default.
- W2018798499 creator A5051005847 @default.
- W2018798499 creator A5053031759 @default.
- W2018798499 creator A5064989058 @default.
- W2018798499 creator A5067150322 @default.
- W2018798499 creator A5072199835 @default.
- W2018798499 date "2010-07-14" @default.
- W2018798499 modified "2023-10-18" @default.
- W2018798499 title "Cardiac malformations in Pdgfrα mutant embryos are associated with increased expression of WT1 and Nkx2.5 in the second heart field" @default.
- W2018798499 cites W1932371007 @default.
- W2018798499 cites W1948282121 @default.
- W2018798499 cites W1969953709 @default.
- W2018798499 cites W1993827678 @default.
- W2018798499 cites W2000168964 @default.
- W2018798499 cites W2003904482 @default.
- W2018798499 cites W2005435367 @default.
- W2018798499 cites W2005451662 @default.
- W2018798499 cites W2006482057 @default.
- W2018798499 cites W2010395737 @default.
- W2018798499 cites W2012434500 @default.
- W2018798499 cites W2016368778 @default.
- W2018798499 cites W2018821001 @default.
- W2018798499 cites W2021050699 @default.
- W2018798499 cites W2025923324 @default.
- W2018798499 cites W2027080314 @default.
- W2018798499 cites W2033201483 @default.
- W2018798499 cites W2034454142 @default.
- W2018798499 cites W2043741773 @default.
- W2018798499 cites W2055752082 @default.
- W2018798499 cites W2062209057 @default.
- W2018798499 cites W2063416138 @default.
- W2018798499 cites W2075396495 @default.
- W2018798499 cites W2077709091 @default.
- W2018798499 cites W2082743101 @default.
- W2018798499 cites W2085270120 @default.
- W2018798499 cites W2092389279 @default.
- W2018798499 cites W2102258222 @default.
- W2018798499 cites W2106458308 @default.
- W2018798499 cites W2115599237 @default.
- W2018798499 cites W2121442685 @default.
- W2018798499 cites W2122972967 @default.
- W2018798499 cites W2123808459 @default.
- W2018798499 cites W2127683916 @default.
- W2018798499 cites W2137302341 @default.
- W2018798499 cites W2142613777 @default.
- W2018798499 cites W2154317625 @default.
- W2018798499 cites W2155412985 @default.
- W2018798499 cites W2161907969 @default.
- W2018798499 cites W2163226372 @default.
- W2018798499 cites W2167116126 @default.
- W2018798499 cites W2186753081 @default.
- W2018798499 doi "https://doi.org/10.1002/dvdy.22363" @default.
- W2018798499 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2911638" @default.
- W2018798499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20658695" @default.
- W2018798499 hasPublicationYear "2010" @default.
- W2018798499 type Work @default.
- W2018798499 sameAs 2018798499 @default.
- W2018798499 citedByCount "52" @default.
- W2018798499 countsByYear W20187984992012 @default.
- W2018798499 countsByYear W20187984992013 @default.
- W2018798499 countsByYear W20187984992014 @default.
- W2018798499 countsByYear W20187984992015 @default.
- W2018798499 countsByYear W20187984992016 @default.
- W2018798499 countsByYear W20187984992017 @default.
- W2018798499 countsByYear W20187984992018 @default.
- W2018798499 countsByYear W20187984992019 @default.
- W2018798499 countsByYear W20187984992020 @default.
- W2018798499 countsByYear W20187984992021 @default.
- W2018798499 countsByYear W20187984992022 @default.
- W2018798499 countsByYear W20187984992023 @default.
- W2018798499 crossrefType "journal-article" @default.
- W2018798499 hasAuthorship W2018798499A5014377544 @default.
- W2018798499 hasAuthorship W2018798499A5015411763 @default.
- W2018798499 hasAuthorship W2018798499A5030802852 @default.
- W2018798499 hasAuthorship W2018798499A5036060072 @default.
- W2018798499 hasAuthorship W2018798499A5038268390 @default.
- W2018798499 hasAuthorship W2018798499A5050395195 @default.
- W2018798499 hasAuthorship W2018798499A5051005847 @default.
- W2018798499 hasAuthorship W2018798499A5053031759 @default.
- W2018798499 hasAuthorship W2018798499A5064989058 @default.
- W2018798499 hasAuthorship W2018798499A5067150322 @default.
- W2018798499 hasAuthorship W2018798499A5072199835 @default.
- W2018798499 hasBestOaLocation W20187984991 @default.
- W2018798499 hasConcept C104317684 @default.
- W2018798499 hasConcept C105702510 @default.
- W2018798499 hasConcept C126322002 @default.
- W2018798499 hasConcept C134018914 @default.
- W2018798499 hasConcept C145103041 @default.
- W2018798499 hasConcept C170493617 @default.
- W2018798499 hasConcept C180361614 @default.
- W2018798499 hasConcept C2775960820 @default.