FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018798842> ?p ?o ?g. }

• W2018798842 endingPage "1303" @default.
• W2018798842 startingPage "1295" @default.
• W2018798842 abstract "Cell‐based therapies using embryonic stem cells (ESCs) in the treatment of neural disease will require the generation of homogenous donor neural progenitor (NP) populations. Here we describe an efficient culture system containing hepatocyte growth factor (HGF) and G5 supplement for the production of highly enriched (88.3% ± 8.1%) populations of NPs from rhesus monkey ESCs. Additional purification resulted in NP preparations that were 98% nestin positive. Moreover, NPs, as monolayers or neurospheres, could be maintained for prolonged periods of time in media containing HGF+G5 or G5 alone. In vitro differentiation and in vivo transplantation assays showed that NPs could differentiate into neurons, astrocytes, and oligodendrocytes. The kinds and quantities of differentiated cells derived from NPs were closely correlated with their niches in vivo. Glial differentiation was predominant in periventricular areas, whereas cells migrating into the cortex were mostly neurons. Cell counts showed that 2 months after transplantation, approximately 25% of transplanted NPs survived and 65%–80% of the surviving transplanted cells migrated along the ventricular wall or in a radial fashion. Subcloning demonstrated that several clonal lines derived from NPs expressed nestin and differentiated into three neural lineages in vitro and in rat brains in vivo. In contrast, some subcloned lines showed restricted differentiation both in vitro and in vivo in rat brains. These observations set the stage for obtaining highly enriched NPs and evaluating the efficacy of NP‐based transplantation therapy in the nonhuman primate and will provide a platform for probing the molecular mechanisms that control neural induction." @default.
• W2018798842 created "2016-06-24" @default.
• W2018798842 creator A5001582203 @default.
• W2018798842 creator A5003787100 @default.
• W2018798842 creator A5007283568 @default.
• W2018798842 creator A5008582313 @default.
• W2018798842 creator A5021983750 @default.
• W2018798842 creator A5050334079 @default.
• W2018798842 creator A5052155414 @default.
• W2018798842 creator A5052647506 @default.
• W2018798842 creator A5052883326 @default.
• W2018798842 creator A5069135894 @default.
• W2018798842 creator A5084741637 @default.
• W2018798842 date "2005-10-01" @default.
• W2018798842 modified "2023-10-14" @default.
• W2018798842 title "Transplantable Neural Progenitor Populations Derived from Rhesus Monkey Embryonic Stem Cells" @default.
• W2018798842 cites W1515519882 @default.
• W2018798842 cites W1595834812 @default.
• W2018798842 cites W1733539716 @default.
• W2018798842 cites W1834737933 @default.
• W2018798842 cites W1963521514 @default.
• W2018798842 cites W1966476278 @default.
• W2018798842 cites W1970774026 @default.
• W2018798842 cites W1983274440 @default.
• W2018798842 cites W1988189150 @default.
• W2018798842 cites W1989920563 @default.
• W2018798842 cites W2001675896 @default.
• W2018798842 cites W2005707140 @default.
• W2018798842 cites W2024957174 @default.
• W2018798842 cites W2032386495 @default.
• W2018798842 cites W2033284482 @default.
• W2018798842 cites W2039824179 @default.
• W2018798842 cites W2041695960 @default.
• W2018798842 cites W2046935089 @default.
• W2018798842 cites W2050983091 @default.
• W2018798842 cites W2055423598 @default.
• W2018798842 cites W2058937717 @default.
• W2018798842 cites W2059759528 @default.
• W2018798842 cites W2061558355 @default.
• W2018798842 cites W2064496329 @default.
• W2018798842 cites W2075284857 @default.
• W2018798842 cites W2079190679 @default.
• W2018798842 cites W2083859960 @default.
• W2018798842 cites W2096436305 @default.
• W2018798842 cites W2101556559 @default.
• W2018798842 cites W2111191613 @default.
• W2018798842 cites W2116715929 @default.
• W2018798842 cites W2130929362 @default.
• W2018798842 cites W2141998956 @default.
• W2018798842 cites W2145441493 @default.
• W2018798842 cites W2147447147 @default.
• W2018798842 cites W2148633182 @default.
• W2018798842 cites W2161264600 @default.
• W2018798842 cites W2253187845 @default.
• W2018798842 doi "https://doi.org/10.1634/stemcells.2005-0026" @default.
• W2018798842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16051986" @default.
• W2018798842 hasPublicationYear "2005" @default.
• W2018798842 type Work @default.
• W2018798842 sameAs 2018798842 @default.
• W2018798842 citedByCount "17" @default.
• W2018798842 countsByYear W20187988422012 @default.
• W2018798842 countsByYear W20187988422013 @default.
• W2018798842 countsByYear W20187988422014 @default.
• W2018798842 countsByYear W20187988422016 @default.
• W2018798842 countsByYear W20187988422017 @default.
• W2018798842 countsByYear W20187988422018 @default.
• W2018798842 crossrefType "journal-article" @default.
• W2018798842 hasAuthorship W2018798842A5001582203 @default.
• W2018798842 hasAuthorship W2018798842A5003787100 @default.
• W2018798842 hasAuthorship W2018798842A5007283568 @default.
• W2018798842 hasAuthorship W2018798842A5008582313 @default.
• W2018798842 hasAuthorship W2018798842A5021983750 @default.
• W2018798842 hasAuthorship W2018798842A5050334079 @default.
• W2018798842 hasAuthorship W2018798842A5052155414 @default.
• W2018798842 hasAuthorship W2018798842A5052647506 @default.
• W2018798842 hasAuthorship W2018798842A5052883326 @default.
• W2018798842 hasAuthorship W2018798842A5069135894 @default.
• W2018798842 hasAuthorship W2018798842A5084741637 @default.
• W2018798842 hasBestOaLocation W20187988421 @default.
• W2018798842 hasConcept C104317684 @default.
• W2018798842 hasConcept C126322002 @default.
• W2018798842 hasConcept C136834591 @default.
• W2018798842 hasConcept C145103041 @default.
• W2018798842 hasConcept C148738053 @default.
• W2018798842 hasConcept C153911025 @default.
• W2018798842 hasConcept C162746124 @default.
• W2018798842 hasConcept C201750760 @default.
• W2018798842 hasConcept C203014093 @default.
• W2018798842 hasConcept C207001950 @default.
• W2018798842 hasConcept C20875687 @default.
• W2018798842 hasConcept C2777738006 @default.
• W2018798842 hasConcept C28328180 @default.
• W2018798842 hasConcept C2911091166 @default.
• W2018798842 hasConcept C54355233 @default.
• W2018798842 hasConcept C71924100 @default.
• W2018798842 hasConcept C86803240 @default.
• W2018798842 hasConcept C95444343 @default.
• W2018798842 hasConceptScore W2018798842C104317684 @default.

• next