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- W2018800513 abstract "Abstract A simple and reliable h.p.l.c. method for the determination of bamipine, hydrocortisone, dexamethasone, betamethasone and beclomethasone has been developed. The procedure, which simultaneously resolves all five compounds, could be employed for the analysis of each component in different pharmaceutical formulations. Chromatographic separation was accomplished under isocratic conditions using a Bondapak 10 μm, C18 column 250x2.1 mm and a mobile phase of acetonitrile: water (48:52) and 0.65% acetic acid pumped at a rate of 1 ml/min. Column effluent was monitored with an U.V. detector at 251 nm. The behaviour (k' values) of the compounds were also investigated under different chromatographic conditions. The compounds were eluted in the range from 2.54 to 8.78 mins. Linearity, reproducibility and recovery (% of labelled amount) were satisfactory for all compounds. The method has been successfully applied to the analysis of ointment, cream, gel and lotion." @default.
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- W2018800513 date "1995-10-01" @default.
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- W2018800513 title "Separation and Determination of Some Corticosteroids Combined with Bamipine in Pharmaceutical Formulations by High Performance Liquid Chromatography" @default.
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- W2018800513 doi "https://doi.org/10.1080/10826079508010466" @default.
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