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- W2018802697 abstract "Abstract We report here the successful prosthetic replacement of cardiac valves in a patient with a severe sickle cell hemoglobinopathy: a 22 year old Negro woman with mitral stenosis, mitral insufficiency, aortic insufficiency and heterozygosity for hemoglobin S and hemoglobin C (hemoglobin SC disease). Clinical severity of her cardiac disease made aortic and mitral valve replacement mandatory, despite lack of adequate precedent for this operation in a patient with severe hemolytic disease and despite the fact that hemoglobin SC erythrocytes are known to be usually susceptible to mechanical trauma. The risk of sickling at operation was diminished by a 70 percent partial exchange transfusion with normal erythrocytes accomplished at the time of cardiac bypass. Red cell fragmentation characteristic of damage by intracardiac prostheses developed and persisted postoperatively, but red cell survival remained unchanged. Cardiac status after 2 1 2 years continues to be markedly improved." @default.
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- W2018802697 date "1971-03-01" @default.
- W2018802697 modified "2023-09-25" @default.
- W2018802697 title "Successful replacement of aortic and mitral valves with ball valve prostheses in a patient with rheumatic heart disease and SC hemoglobinopathy" @default.
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- W2018802697 doi "https://doi.org/10.1016/0002-9149(71)90311-0" @default.
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