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- W2018804075 endingPage "842" @default.
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- W2018804075 abstract "Antiretroviral therapy has reduced the incidence of adverse events and early mortality in HIV-infected persons. Despite these benefits, important comorbidities that increase with age (eg, diabetes, cardiovascular disease, cancer, liver disease, and neurocognitive impairment) are more prevalent in HIV-infected persons than in HIV-uninfected persons at every age, and geriatric syndromes such as falls and frailty occur earlier in HIV-infected persons. This raises a critical research question: Does HIV accelerate aging through pathways and mechanisms common to the aging process or is HIV simply an additional risk factor for a wide number of chronic conditions, thus accentuating aging? Extensive literature review. The purpose of this review is to briefly outline the evidence that age-related clinical syndromes are exacerbated by HIV, examine the ways in which HIV is similar, and dissimilar from natural aging, and assess the validity of HIV as a model of premature aging. Specific biomarkers of aging are limited in HIV-infected hosts and impacted by antiretroviral therapy, and a high rate of modifiable life style confounders (eg, smoking, substance abuse, alcohol) and coinfections (eg, hepatitis) in HIV-infected participants. There is a need for validated biomarkers of aging in the context of HIV. Despite these differences, welldesigned studies of HIV-infected participants are likely to provide new opportunities to better understand the mechanisms that lead to aging and age-related diseases." @default.
- W2018804075 created "2016-06-24" @default.
- W2018804075 creator A5016102389 @default.
- W2018804075 creator A5023520658 @default.
- W2018804075 creator A5035175377 @default.
- W2018804075 creator A5052468100 @default.
- W2018804075 date "2013-10-24" @default.
- W2018804075 modified "2023-10-17" @default.
- W2018804075 title "Is HIV a Model of Accelerated or Accentuated Aging?" @default.
- W2018804075 cites W1497170016 @default.
- W2018804075 cites W1553612782 @default.
- W2018804075 cites W1573558157 @default.
- W2018804075 cites W1965749245 @default.
- W2018804075 cites W1966370842 @default.
- W2018804075 cites W1966715536 @default.
- W2018804075 cites W1967879506 @default.
- W2018804075 cites W1968134248 @default.
- W2018804075 cites W1968708587 @default.
- W2018804075 cites W1968900892 @default.
- W2018804075 cites W1969189285 @default.
- W2018804075 cites W1978749267 @default.
- W2018804075 cites W1981212269 @default.
- W2018804075 cites W1986151024 @default.
- W2018804075 cites W1986763065 @default.
- W2018804075 cites W1988707875 @default.
- W2018804075 cites W1992604744 @default.
- W2018804075 cites W1994481430 @default.
- W2018804075 cites W1999929128 @default.
- W2018804075 cites W2002933376 @default.
- W2018804075 cites W2003020102 @default.
- W2018804075 cites W2005240331 @default.
- W2018804075 cites W2010686257 @default.
- W2018804075 cites W2011490846 @default.
- W2018804075 cites W2013147097 @default.
- W2018804075 cites W2014165420 @default.
- W2018804075 cites W2016336666 @default.
- W2018804075 cites W2016488838 @default.
- W2018804075 cites W2017605567 @default.
- W2018804075 cites W2020759754 @default.
- W2018804075 cites W2027974475 @default.
- W2018804075 cites W2028169108 @default.
- W2018804075 cites W2029012724 @default.
- W2018804075 cites W2031041877 @default.
- W2018804075 cites W2033149855 @default.
- W2018804075 cites W2033479376 @default.
- W2018804075 cites W2035121127 @default.
- W2018804075 cites W2038998835 @default.
- W2018804075 cites W2044460884 @default.
- W2018804075 cites W2044981316 @default.
- W2018804075 cites W2049614028 @default.
- W2018804075 cites W2058807541 @default.
- W2018804075 cites W2059896966 @default.
- W2018804075 cites W2068703170 @default.
- W2018804075 cites W2070299935 @default.
- W2018804075 cites W2085716301 @default.
- W2018804075 cites W2088000974 @default.
- W2018804075 cites W2088934391 @default.
- W2018804075 cites W2095748010 @default.
- W2018804075 cites W2096736732 @default.
- W2018804075 cites W2098152094 @default.
- W2018804075 cites W2104996267 @default.
- W2018804075 cites W2105804574 @default.
- W2018804075 cites W2109413245 @default.
- W2018804075 cites W2110559078 @default.
- W2018804075 cites W2113308383 @default.
- W2018804075 cites W2115364134 @default.
- W2018804075 cites W2115852450 @default.
- W2018804075 cites W2117563330 @default.
- W2018804075 cites W2118020641 @default.
- W2018804075 cites W2118399528 @default.
- W2018804075 cites W2118627939 @default.
- W2018804075 cites W2122483069 @default.
- W2018804075 cites W2125243069 @default.
- W2018804075 cites W2127031590 @default.
- W2018804075 cites W2132466754 @default.
- W2018804075 cites W2135397849 @default.
- W2018804075 cites W2137427952 @default.
- W2018804075 cites W2137494118 @default.
- W2018804075 cites W2145073109 @default.
- W2018804075 cites W2145677576 @default.
- W2018804075 cites W2146353879 @default.
- W2018804075 cites W2148314152 @default.
- W2018804075 cites W2148327106 @default.
- W2018804075 cites W2148597851 @default.
- W2018804075 cites W2150484278 @default.
- W2018804075 cites W2153136696 @default.
- W2018804075 cites W2157856009 @default.
- W2018804075 cites W2158298030 @default.
- W2018804075 cites W2160608100 @default.
- W2018804075 cites W2160880676 @default.
- W2018804075 cites W2162694378 @default.
- W2018804075 cites W2164059021 @default.
- W2018804075 cites W2171523916 @default.
- W2018804075 cites W2326971876 @default.
- W2018804075 cites W4231719195 @default.
- W2018804075 cites W4236388726 @default.
- W2018804075 doi "https://doi.org/10.1093/gerona/glt168" @default.
- W2018804075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4067117" @default.