Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018804968> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2018804968 endingPage "268" @default.
- W2018804968 startingPage "263" @default.
- W2018804968 abstract "Abstract The aim of this study was to determine the effect of FR183998 (5-(2,5-dichlorothiophen-3-yl)-3-[(2-dimethylaminoethyl)carbamoyl]benzoylguanidine dihydrochloride), an Na+/H+ exchange inhibitor, on myocardial interleukin-8 (IL-8) content and myocardial infarct size in a rat ischaemia and reperfusion model. Rats underwent30 min of ischaemia followed by 1 to 24 h of reperfusion. IL-8 content rapidly increased in reperfused rat hearts. The maximum increase in IL-8 was obtained after 3 h of reperfusion. Intravenous administration of FR183998 at 1 and 3.2 mg kg−1, 5 min before ischaemia, significantly reduced the IL-8 level after 3 h of reperfusion (122 ± 16 and 149 ± 23 pg mg−1 protein, respectively), compared with that of the saline-treated group (258 ± 27 pg mg−1 protein). Myeloperoxidase activity after 3 h of reperfusion was also reduced by FR183998 (from 0.83 ± 0.19 unit g−1 weight of tissue in the saline-treated group to 0.36 ± 0.09 and 0.33 ± 0.06 unit g−1 weight of tissue in FR183998-treated groups at 1.0 and 3.2 mg kg−1, respectively). Myocardial infarction induced by 30 min of ischaemia and 24 h of reperfusion was significantly suppressed by the same doses of FR183998 (14.0 ± 1.5,13.5 ± 1.9% at 1.0 and 3.2 mg kg−1), compared with 22.2 ± 2.7% in the saline-treated group. These results suggest that IL-8 may contribute to the generation of myocardial infarction in an ischaemia and reperfusion model in rats." @default.
- W2018804968 created "2016-06-24" @default.
- W2018804968 creator A5006227445 @default.
- W2018804968 creator A5030838226 @default.
- W2018804968 creator A5044623712 @default.
- W2018804968 creator A5055652136 @default.
- W2018804968 creator A5084388249 @default.
- W2018804968 date "2002-02-01" @default.
- W2018804968 modified "2023-10-18" @default.
- W2018804968 title "FR183998, a Na+/H+ exchange inhibitor, suppresses both IL-8 content and myocardial infarct size in a cardiac ischaemia-reperfusion model in rats" @default.
- W2018804968 cites W1509551118 @default.
- W2018804968 cites W1536629235 @default.
- W2018804968 cites W1600368065 @default.
- W2018804968 cites W1968409023 @default.
- W2018804968 cites W1975742983 @default.
- W2018804968 cites W1983533768 @default.
- W2018804968 cites W1984483543 @default.
- W2018804968 cites W1999730887 @default.
- W2018804968 cites W2043670699 @default.
- W2018804968 cites W2047563687 @default.
- W2018804968 cites W2081662576 @default.
- W2018804968 cites W2112568641 @default.
- W2018804968 cites W2123884323 @default.
- W2018804968 cites W2129042092 @default.
- W2018804968 cites W2151067784 @default.
- W2018804968 cites W2166123671 @default.
- W2018804968 cites W2181320613 @default.
- W2018804968 cites W4302464931 @default.
- W2018804968 doi "https://doi.org/10.1211/0022357021778295" @default.
- W2018804968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11848290" @default.
- W2018804968 hasPublicationYear "2002" @default.
- W2018804968 type Work @default.
- W2018804968 sameAs 2018804968 @default.
- W2018804968 citedByCount "5" @default.
- W2018804968 countsByYear W20188049682013 @default.
- W2018804968 countsByYear W20188049682022 @default.
- W2018804968 crossrefType "journal-article" @default.
- W2018804968 hasAuthorship W2018804968A5006227445 @default.
- W2018804968 hasAuthorship W2018804968A5030838226 @default.
- W2018804968 hasAuthorship W2018804968A5044623712 @default.
- W2018804968 hasAuthorship W2018804968A5055652136 @default.
- W2018804968 hasAuthorship W2018804968A5084388249 @default.
- W2018804968 hasBestOaLocation W20188049681 @default.
- W2018804968 hasConcept C126322002 @default.
- W2018804968 hasConcept C134018914 @default.
- W2018804968 hasConcept C203565725 @default.
- W2018804968 hasConcept C2776914184 @default.
- W2018804968 hasConcept C2777397205 @default.
- W2018804968 hasConcept C2777798775 @default.
- W2018804968 hasConcept C2780114680 @default.
- W2018804968 hasConcept C42219234 @default.
- W2018804968 hasConcept C500558357 @default.
- W2018804968 hasConcept C541997718 @default.
- W2018804968 hasConcept C71924100 @default.
- W2018804968 hasConceptScore W2018804968C126322002 @default.
- W2018804968 hasConceptScore W2018804968C134018914 @default.
- W2018804968 hasConceptScore W2018804968C203565725 @default.
- W2018804968 hasConceptScore W2018804968C2776914184 @default.
- W2018804968 hasConceptScore W2018804968C2777397205 @default.
- W2018804968 hasConceptScore W2018804968C2777798775 @default.
- W2018804968 hasConceptScore W2018804968C2780114680 @default.
- W2018804968 hasConceptScore W2018804968C42219234 @default.
- W2018804968 hasConceptScore W2018804968C500558357 @default.
- W2018804968 hasConceptScore W2018804968C541997718 @default.
- W2018804968 hasConceptScore W2018804968C71924100 @default.
- W2018804968 hasIssue "2" @default.
- W2018804968 hasLocation W20188049681 @default.
- W2018804968 hasLocation W20188049682 @default.
- W2018804968 hasOpenAccess W2018804968 @default.
- W2018804968 hasPrimaryLocation W20188049681 @default.
- W2018804968 hasRelatedWork W2009877402 @default.
- W2018804968 hasRelatedWork W2011598966 @default.
- W2018804968 hasRelatedWork W2014432291 @default.
- W2018804968 hasRelatedWork W2023991882 @default.
- W2018804968 hasRelatedWork W2054119993 @default.
- W2018804968 hasRelatedWork W2056503472 @default.
- W2018804968 hasRelatedWork W2071934027 @default.
- W2018804968 hasRelatedWork W2372766257 @default.
- W2018804968 hasRelatedWork W2379474544 @default.
- W2018804968 hasRelatedWork W91566620 @default.
- W2018804968 hasVolume "54" @default.
- W2018804968 isParatext "false" @default.
- W2018804968 isRetracted "false" @default.
- W2018804968 magId "2018804968" @default.
- W2018804968 workType "article" @default.