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- W2018817967 abstract "It seems that the efficacy of aripiprazole for treating schizophrenia is mediated through a combination of partial agonism at dopamine D2 and serotonin 5-HT1A receptors and antagonism at serotonin 5-HT2A receptors. Aripiprazole has also received approval for the treatment of bipolar disorder as adjunctive therapy or monotherapy (manic or mixed episodes) as well as an augmentation therapy of major depressive disorder (MDD) by the US FDA. The overall safety and tolerability of aripiprazole is favorable compared to other atypical antipsychotics across the approved indications. Aripiprazole showed a minimal propensity for clinically significant weight gain and metabolic disruption. However, extrapyramidal side effects, such as akathisia, are reported and may limit its clinical use in some cases, particularly in patients with bipolar disorder and MDD. This review focuses on the tolerability and safety of aripiprazole across a broad spectrum of psychiatric disorders while taking into consideration results from registrational studies as well as findings from studies in the naturalistic setting. In conclusion, whereas the comparative safety and tolerability of aripiprazole has not been systematically evaluated in comparator studies, tolerability and safety issues commonly associated with atypical antipsychotics such as weight gain and metabolic syndrome are less prominent with aripiprazole." @default.
- W2018817967 created "2016-06-24" @default.
- W2018817967 creator A5006428625 @default.
- W2018817967 date "2009-05-01" @default.
- W2018817967 modified "2023-10-16" @default.
- W2018817967 title "A review of the safety and tolerability of aripiprazole" @default.
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- W2018817967 doi "https://doi.org/10.1517/14740330902835493" @default.
- W2018817967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19505266" @default.
- W2018817967 hasPublicationYear "2009" @default.
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