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- W2018838067 abstract "Using single-cell microfluorimetry, we have shown that ATP evoked repetitive Ca2+ oscillations in intact Fura-2 loaded human granulosa-luteal cells (hG/LCs) in the absence of extracellular Ca2+. Sustained increases in [Ca2+]i required extracellular Ca2+ and ATP depleted stores were refreshed by brief (2 min) incubation with external Ca2+ Basal [Ca2+]i was unaffected by caffeine (1 mM), but 20 mM caffeine inhibited ATP-evoked Ca2+ release in the absence of external Ca2+. Thimerosal (10 μM) evoked repetitive Ca2+ spikes, under Ca2+-free conditions, which fused to form an elevated plateau when external Ca2+ was replaced. Thimerosal-induced changes in [Ca2+]i were reversibly inhibited by the thiol reducing agent dithiothreitol (1 mM). The periodicity and amplitude of the [Ca2+]i oscillations produced by thimerosal and ATP differ. ATP- or thimerosal-evoked changes in [Ca2+]i were unaffected by dantrolene sodium (10 μM). The Ca2+-ATPase inhibitor thapsigargin (1 μM) increased [Ca2+]i and attenuated subsequent ATP-evoked changes in [Ca2+]i. We conclude that ATP stimulates an oscillatory release of Ca2+ from InsP3-sensitive stores in hG/LCs." @default.
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- W2018838067 date "1997-05-01" @default.
- W2018838067 modified "2023-09-26" @default.
- W2018838067 title "Mechanisms involved in ATP-evoked Ca2+ oscillations in isolated human granulosa-luteal cells" @default.
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- W2018838067 doi "https://doi.org/10.1016/s0143-4160(97)90030-0" @default.
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