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• W2018843772 abstract "The interaction between the fragile X mental retardation protein (FMRP) and BC1 RNA has been the subject of controversy. We probed the parameters of RNA binding to FMRP in several ways. Nondenaturing agarose gel analysis showed that BC1 RNA transcripts produced by in vitro transcription contain a population of conformers, which can be modulated by preannealing. Accordingly, FMRP differentially binds to the annealed and unannealed conformer populations. Using partial RNase digestion, we demonstrate that annealed BC1 RNA contains a unique conformer that FMRP likely binds. We further demonstrate that this interaction is 100-fold weaker than that the binding of eEF-1A mRNA and FMRP, and that preannealing is not a general requirement for FMRP's interaction with RNA. In addition, binding does not require the N-terminal 204 amino acids of FMRP, methylated arginine residues and can be recapitulated by both fragile X paralogs. Altogether, our data continue to support a model in which BC1 RNA functions independently of FMRP." @default.
• W2018843772 created "2016-06-24" @default.
• W2018843772 creator A5029219765 @default.
• W2018843772 creator A5073687242 @default.
• W2018843772 date "2011-01-01" @default.
• W2018843772 modified "2023-10-02" @default.
• W2018843772 title "Conformational-Dependent and Independent RNA Binding to the Fragile X Mental Retardation Protein" @default.
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• W2018843772 doi "https://doi.org/10.4061/2011/246127" @default.
• W2018843772 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3136132" @default.
• W2018843772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21772992" @default.
• W2018843772 hasPublicationYear "2011" @default.
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