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- W2018846486 abstract "The subthalamic nucleus (STN) of the basal ganglia is an important element of motor control. This is demonstrated by involuntary movements induced by STN lesions and the successful treatment of Parkinson's disease by STN stimulation. However, it is still unclear how individual STN neurons participate in motor control. Here, we report that the STN has a function in switching from automatic to volitionally controlled eye movement. In the STN of trained macaque monkeys, we found neurons that showed a phasic change in activity specifically before volitionally controlled saccades which were switched from automatic saccades. A majority of switch-related neurons were considered to inhibit no-longer-valid automatic processes, and the inhibition started early enough to enable the animal to switch. We suggest that the STN mediates the control signal originated from the medial frontal cortex and implements the behavioral switching function using its connections with other basal ganglia nuclei and the superior colliculus." @default.
- W2018846486 created "2016-06-24" @default.
- W2018846486 creator A5009985808 @default.
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- W2018846486 date "2008-07-09" @default.
- W2018846486 modified "2023-10-10" @default.
- W2018846486 title "Role for Subthalamic Nucleus Neurons in Switching from Automatic to Controlled Eye Movement" @default.
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- W2018846486 doi "https://doi.org/10.1523/jneurosci.0487-08.2008" @default.
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