FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018848384> ?p ?o ?g. }

• W2018848384 endingPage "6749" @default.
• W2018848384 startingPage "6741" @default.
• W2018848384 abstract "Improving cellular uptake and biodistribution remains one of the major obstacles for a successful and broad application of peptide nucleic acids (PNAs) as antisense therapeutics. Recently, we reported the identification and functional characterization of an antisense PNA, which redirects splicing of murine CD40 pre-mRNA. In this context, it was discovered that a simple octa(l-lysine) peptide covalently linked to the PNA is capable of promoting free uptake of the conjugate into BCL1 cells as well as primary murine macrophages. On the basis of this peptide motif, the present study aimed at identifying the structural features, which define effective peptide carriers for cellular delivery of PNA. While the structure−activity relationship study revealed some clear correlations, only a few modifications actually led to an overall improvement as compared to the parent octa(l-lysine) conjugate. In a preliminary PK/tissue distribution study in healthy mice, the parent conjugate exhibited relatively broad tissue distribution and only modest elimination via excretion within the time frame of the study." @default.
• W2018848384 created "2016-06-24" @default.
• W2018848384 creator A5002284392 @default.
• W2018848384 creator A5009098620 @default.
• W2018848384 creator A5018505403 @default.
• W2018848384 creator A5021253347 @default.
• W2018848384 creator A5038908901 @default.
• W2018848384 creator A5044334898 @default.
• W2018848384 creator A5044758297 @default.
• W2018848384 creator A5052019928 @default.
• W2018848384 creator A5056173478 @default.
• W2018848384 creator A5056554811 @default.
• W2018848384 creator A5059837626 @default.
• W2018848384 creator A5065703477 @default.
• W2018848384 creator A5072241904 @default.
• W2018848384 creator A5083296071 @default.
• W2018848384 creator A5085203302 @default.
• W2018848384 creator A5086886197 @default.
• W2018848384 date "2005-09-15" @default.
• W2018848384 modified "2023-09-27" @default.
• W2018848384 title "Structure−Activity Relationship Study on a Simple Cationic Peptide Motif for Cellular Delivery of Antisense Peptide Nucleic Acid" @default.
• W2018848384 cites W1574601702 @default.
• W2018848384 cites W1584683177 @default.
• W2018848384 cites W1966640620 @default.
• W2018848384 cites W1967173876 @default.
• W2018848384 cites W1969217480 @default.
• W2018848384 cites W1987194067 @default.
• W2018848384 cites W1997096397 @default.
• W2018848384 cites W2002514150 @default.
• W2018848384 cites W2003066928 @default.
• W2018848384 cites W2006998980 @default.
• W2018848384 cites W2010659535 @default.
• W2018848384 cites W2019818589 @default.
• W2018848384 cites W2029346749 @default.
• W2018848384 cites W2032178581 @default.
• W2018848384 cites W2038720675 @default.
• W2018848384 cites W2040885207 @default.
• W2018848384 cites W2058975342 @default.
• W2018848384 cites W2060834298 @default.
• W2018848384 cites W2064365201 @default.
• W2018848384 cites W2075781213 @default.
• W2018848384 cites W2076283853 @default.
• W2018848384 cites W2077886045 @default.
• W2018848384 cites W2109044040 @default.
• W2018848384 cites W2111994795 @default.
• W2018848384 cites W2123650819 @default.
• W2018848384 cites W2169019691 @default.
• W2018848384 cites W428907568 @default.
• W2018848384 doi "https://doi.org/10.1021/jm050490b" @default.
• W2018848384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16220989" @default.
• W2018848384 hasPublicationYear "2005" @default.
• W2018848384 type Work @default.
• W2018848384 sameAs 2018848384 @default.
• W2018848384 citedByCount "34" @default.
• W2018848384 countsByYear W20188483842012 @default.
• W2018848384 countsByYear W20188483842013 @default.
• W2018848384 countsByYear W20188483842014 @default.
• W2018848384 countsByYear W20188483842015 @default.
• W2018848384 countsByYear W20188483842016 @default.
• W2018848384 countsByYear W20188483842018 @default.
• W2018848384 countsByYear W20188483842020 @default.
• W2018848384 countsByYear W20188483842021 @default.
• W2018848384 countsByYear W20188483842022 @default.
• W2018848384 crossrefType "journal-article" @default.
• W2018848384 hasAuthorship W2018848384A5002284392 @default.
• W2018848384 hasAuthorship W2018848384A5009098620 @default.
• W2018848384 hasAuthorship W2018848384A5018505403 @default.
• W2018848384 hasAuthorship W2018848384A5021253347 @default.
• W2018848384 hasAuthorship W2018848384A5038908901 @default.
• W2018848384 hasAuthorship W2018848384A5044334898 @default.
• W2018848384 hasAuthorship W2018848384A5044758297 @default.
• W2018848384 hasAuthorship W2018848384A5052019928 @default.
• W2018848384 hasAuthorship W2018848384A5056173478 @default.
• W2018848384 hasAuthorship W2018848384A5056554811 @default.
• W2018848384 hasAuthorship W2018848384A5059837626 @default.
• W2018848384 hasAuthorship W2018848384A5065703477 @default.
• W2018848384 hasAuthorship W2018848384A5072241904 @default.
• W2018848384 hasAuthorship W2018848384A5083296071 @default.
• W2018848384 hasAuthorship W2018848384A5085203302 @default.
• W2018848384 hasAuthorship W2018848384A5086886197 @default.
• W2018848384 hasConcept C104317684 @default.
• W2018848384 hasConcept C132677234 @default.
• W2018848384 hasConcept C134306372 @default.
• W2018848384 hasConcept C153911025 @default.
• W2018848384 hasConcept C185592680 @default.
• W2018848384 hasConcept C197336794 @default.
• W2018848384 hasConcept C202751555 @default.
• W2018848384 hasConcept C24107716 @default.
• W2018848384 hasConcept C2776016237 @default.
• W2018848384 hasConcept C2777343594 @default.
• W2018848384 hasConcept C2777807558 @default.
• W2018848384 hasConcept C2779281246 @default.
• W2018848384 hasConcept C33923547 @default.
• W2018848384 hasConcept C515207424 @default.
• W2018848384 hasConcept C54458228 @default.
• W2018848384 hasConcept C55493867 @default.
• W2018848384 hasConcept C67705224 @default.
• W2018848384 hasConcept C86803240 @default.

• next