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- W2018848468 endingPage "1104" @default.
- W2018848468 startingPage "1091" @default.
- W2018848468 abstract "Oligonucleotides, including antisense oligonucleotides and siRNA, are promising therapeutic agents against a variety of diseases. Effective delivery of these molecules is critical in view of their clinical application. Therefore, cation-based nanoplexes have been developed to improve the stability as well as the intracellular penetration of these short fragments of nucleic acids. However, this approach is clearly limited by the strong interaction with proteins after administration and by the inherent toxicity of these positively charged transfection materials. Neutral lipid–oligonucleotide conjugates have become a subject of considerable interest to improve the safe delivery of oligonucleotides. These molecules have been chemically conjugated to hydrophobic moieties such as cholesterol, squalene, or fatty acids to enhance their pharmacokinetic behavior and trans-membrane delivery. The present review gives an account of the main synthetic methods available to conjugate lipids to oligonucleotides and will discuss the pharmacological efficacy of this approach." @default.
- W2018848468 created "2016-06-24" @default.
- W2018848468 creator A5013203026 @default.
- W2018848468 creator A5015623429 @default.
- W2018848468 creator A5057781231 @default.
- W2018848468 creator A5078174247 @default.
- W2018848468 creator A5090022951 @default.
- W2018848468 date "2012-03-15" @default.
- W2018848468 modified "2023-10-16" @default.
- W2018848468 title "Lipid Conjugated Oligonucleotides: A Useful Strategy for Delivery" @default.
- W2018848468 cites W1881967720 @default.
- W2018848468 cites W1966660791 @default.
- W2018848468 cites W1966942560 @default.
- W2018848468 cites W1970679679 @default.
- W2018848468 cites W1971975619 @default.
- W2018848468 cites W1975256590 @default.
- W2018848468 cites W1976060898 @default.
- W2018848468 cites W1977841850 @default.
- W2018848468 cites W1978057048 @default.
- W2018848468 cites W1978363645 @default.
- W2018848468 cites W1978412576 @default.
- W2018848468 cites W1978542189 @default.
- W2018848468 cites W1984085632 @default.
- W2018848468 cites W1984307295 @default.
- W2018848468 cites W1986302681 @default.
- W2018848468 cites W1988927400 @default.
- W2018848468 cites W1990567087 @default.
- W2018848468 cites W1991346159 @default.
- W2018848468 cites W1994603345 @default.
- W2018848468 cites W1994983564 @default.
- W2018848468 cites W1996825997 @default.
- W2018848468 cites W2003314713 @default.
- W2018848468 cites W2003758982 @default.
- W2018848468 cites W2005381620 @default.
- W2018848468 cites W2007888673 @default.
- W2018848468 cites W2008995354 @default.
- W2018848468 cites W2011372915 @default.
- W2018848468 cites W2011947858 @default.
- W2018848468 cites W2012759160 @default.
- W2018848468 cites W2012931740 @default.
- W2018848468 cites W2013043328 @default.
- W2018848468 cites W2013530347 @default.
- W2018848468 cites W2014509855 @default.
- W2018848468 cites W2014921813 @default.
- W2018848468 cites W2015704490 @default.
- W2018848468 cites W2016203141 @default.
- W2018848468 cites W2022179846 @default.
- W2018848468 cites W2024244702 @default.
- W2018848468 cites W2031493003 @default.
- W2018848468 cites W2034709592 @default.
- W2018848468 cites W2037180864 @default.
- W2018848468 cites W2039233503 @default.
- W2018848468 cites W2039457108 @default.
- W2018848468 cites W2039968823 @default.
- W2018848468 cites W2043457331 @default.
- W2018848468 cites W2045511459 @default.
- W2018848468 cites W2046456508 @default.
- W2018848468 cites W2055119381 @default.
- W2018848468 cites W2057587221 @default.
- W2018848468 cites W2059884965 @default.
- W2018848468 cites W2061812894 @default.
- W2018848468 cites W2063425994 @default.
- W2018848468 cites W2063915751 @default.
- W2018848468 cites W2064093490 @default.
- W2018848468 cites W2064188840 @default.
- W2018848468 cites W2064667228 @default.
- W2018848468 cites W2065480841 @default.
- W2018848468 cites W2065783128 @default.
- W2018848468 cites W2068422066 @default.
- W2018848468 cites W2070390661 @default.
- W2018848468 cites W2071230707 @default.
- W2018848468 cites W2071596792 @default.
- W2018848468 cites W2073244815 @default.
- W2018848468 cites W2074105595 @default.
- W2018848468 cites W2075451769 @default.
- W2018848468 cites W2076011658 @default.
- W2018848468 cites W2078150511 @default.
- W2018848468 cites W2082213106 @default.
- W2018848468 cites W2083556258 @default.
- W2018848468 cites W2085069351 @default.
- W2018848468 cites W2086879201 @default.
- W2018848468 cites W2090160156 @default.
- W2018848468 cites W2090694068 @default.
- W2018848468 cites W2091481083 @default.
- W2018848468 cites W2091557759 @default.
- W2018848468 cites W2091704235 @default.
- W2018848468 cites W2095151181 @default.
- W2018848468 cites W2096018896 @default.
- W2018848468 cites W2097131232 @default.
- W2018848468 cites W2099814598 @default.
- W2018848468 cites W2110083155 @default.
- W2018848468 cites W2112719371 @default.
- W2018848468 cites W2113117576 @default.
- W2018848468 cites W2116424844 @default.
- W2018848468 cites W2117727181 @default.
- W2018848468 cites W2121045072 @default.
- W2018848468 cites W2121133384 @default.
- W2018848468 cites W2125684318 @default.