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• W2018857158 endingPage "855" @default.
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• W2018857158 abstract "The redox-active tripeptide glutathione is an endogenous reducing agent that is found in abundance and throughout the cell. In the endoplasmic reticulum (ER), the ratio of glutathione to glutathione disulfide is lower compared with non-secretory organelles. This relatively oxidizing thiol-disulfide milieu is essential for the oxidative folding of nascent proteins in the ER and, at least in part, maintained by the activity of ER-resident endoplasmic oxidoreductin 1 (Ero1) enzymes that oxidize cysteine side chains at the expense of molecular oxygen. Glutathione disulfide and hydrogen peroxide formed as a consequence of Ero1 activity are widely considered as being inoperative and potentially dangerous by-products of oxidative protein folding in the ER. In contrast to this common view, this Commentary highlights the importance of glutathione- and non glutathione-based homeostatic redox control mechanisms in the ER. Stability in the thiol–disulfide system that prominently includes the protein disulfide isomerases is ensured by the contribution of tightly regulated Ero1 activity, ER-resident peroxidases and the glutathione–glutathione-disulfide redox pair that acts as a potent housekeeper of redox balance. Accordingly, the widely held concept that Ero1-mediated over-oxidation in the ER constitutes a common cause of cellular demise is critically re-evaluated." @default.
• W2018857158 created "2016-06-24" @default.
• W2018857158 creator A5030346632 @default.
• W2018857158 date "2011-03-15" @default.
• W2018857158 modified "2023-10-14" @default.
• W2018857158 title "Glutathione- and non-glutathione-based oxidant control in the endoplasmic reticulum" @default.
• W2018857158 cites W1522763255 @default.
• W2018857158 cites W1530972565 @default.
• W2018857158 cites W1563504653 @default.
• W2018857158 cites W1965745205 @default.
• W2018857158 cites W1971478784 @default.
• W2018857158 cites W1972197918 @default.
• W2018857158 cites W1976161806 @default.
• W2018857158 cites W1980216017 @default.
• W2018857158 cites W1981820162 @default.
• W2018857158 cites W1986164963 @default.
• W2018857158 cites W1986794875 @default.
• W2018857158 cites W1987929062 @default.
• W2018857158 cites W1988862712 @default.
• W2018857158 cites W1995565650 @default.
• W2018857158 cites W1996826558 @default.
• W2018857158 cites W1998049513 @default.
• W2018857158 cites W2000805812 @default.
• W2018857158 cites W2008656776 @default.
• W2018857158 cites W2008905006 @default.
• W2018857158 cites W2010250072 @default.
• W2018857158 cites W2010478212 @default.
• W2018857158 cites W2013646121 @default.
• W2018857158 cites W2016068398 @default.
• W2018857158 cites W2017789801 @default.
• W2018857158 cites W2021727296 @default.
• W2018857158 cites W2023677624 @default.
• W2018857158 cites W2028524030 @default.
• W2018857158 cites W2029112137 @default.
• W2018857158 cites W2031591517 @default.
• W2018857158 cites W2033058426 @default.
• W2018857158 cites W2033133173 @default.
• W2018857158 cites W2034567067 @default.
• W2018857158 cites W2035831124 @default.
• W2018857158 cites W2036603507 @default.
• W2018857158 cites W2037847999 @default.
• W2018857158 cites W2043322219 @default.
• W2018857158 cites W2046018661 @default.
• W2018857158 cites W2050994990 @default.
• W2018857158 cites W2055199664 @default.
• W2018857158 cites W2056840435 @default.
• W2018857158 cites W2059586921 @default.
• W2018857158 cites W2064194224 @default.
• W2018857158 cites W2066338010 @default.
• W2018857158 cites W2066939485 @default.
• W2018857158 cites W2067957695 @default.
• W2018857158 cites W2068381385 @default.
• W2018857158 cites W2068944453 @default.
• W2018857158 cites W2069106612 @default.
• W2018857158 cites W2069268753 @default.
• W2018857158 cites W2071717526 @default.
• W2018857158 cites W2075819863 @default.
• W2018857158 cites W2075922976 @default.
• W2018857158 cites W2077106628 @default.
• W2018857158 cites W2080091995 @default.
• W2018857158 cites W2081132917 @default.
• W2018857158 cites W2081314200 @default.
• W2018857158 cites W2083278580 @default.
• W2018857158 cites W2088913673 @default.
• W2018857158 cites W2100811292 @default.
• W2018857158 cites W2102248384 @default.
• W2018857158 cites W2104431515 @default.
• W2018857158 cites W2105405279 @default.
• W2018857158 cites W2112195082 @default.
• W2018857158 cites W2112288894 @default.
• W2018857158 cites W2112902148 @default.
• W2018857158 cites W2116900685 @default.
• W2018857158 cites W2118178280 @default.
• W2018857158 cites W2119186302 @default.
• W2018857158 cites W2122341467 @default.
• W2018857158 cites W2124334491 @default.
• W2018857158 cites W2125136235 @default.
• W2018857158 cites W2128403738 @default.
• W2018857158 cites W2129632486 @default.
• W2018857158 cites W2131632095 @default.
• W2018857158 cites W2139568257 @default.
• W2018857158 cites W2142467481 @default.
• W2018857158 cites W2146774140 @default.
• W2018857158 cites W2150202137 @default.
• W2018857158 cites W2150277507 @default.
• W2018857158 cites W2150815175 @default.
• W2018857158 cites W2152116743 @default.
• W2018857158 cites W2155945227 @default.
• W2018857158 cites W2158196678 @default.
• W2018857158 cites W2164813266 @default.
• W2018857158 cites W2168158378 @default.
• W2018857158 doi "https://doi.org/10.1242/jcs.080895" @default.
• W2018857158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21378306" @default.
• W2018857158 hasPublicationYear "2011" @default.
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