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• W2018861208 abstract "In Brief BACKGROUND: Nitrous oxide (N2O) delivered at a concentration <50% is accepted as a minimal sedation drug by both the American Society of Anesthesiologists and the American Academy of Pediatrics. The expected level of sedation at an N2O concentration >50% is less clear. METHODS: We conducted a retrospective chart review for all children receiving N2O for procedural sedation at Children's Hospitals and Clinics of Minnesota. Patient age, maximal N2O concentration, duration of N2O administration, completion of procedure, and adverse events were recorded. Level of sedation was assessed on a 0 to 6 scale. RESULTS: N2O was administered on 1858 occasions to 1585 patients younger than 18 years. Most administrations (91.3%) were N2O concentration >50%. Level of sedation scores were as follows: 6 (inadequate) = 1.3%; 5 (minimal) = 94.3%; and 4 (drowsy) = 4.3%; no patient reached a sedation score <4. Fifty-nine patients (3.3%) had adverse events of which 6 (0.3%) were atypical. There was no difference between N2O ≤50% and N2O >50% in the level of sedation or number of adverse events. More children ≤2 years (7.4%) achieved a sedation level of 4 than those older than 2 years (4%), but they experienced a similar rate of adverse events. There was no difference in the level of sedation by duration of N2O administration. Inadequately sedated patients were younger than the remainder of the group. Most procedures (94.1%) were completed with the patient calm and still. CONCLUSIONS: A significant number of children remain minimally sedated while receiving N2O at concentrations >50% via nasal hood using a system designed to titrate N2O concentration from 0% to 70%. Adverse event rates of patients receiving >50% N2O in this manner are similar to rates reported in large studies of 50% N2O administration. Published ahead of print March 17, 2010" @default.
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• W2018861208 date "2010-05-01" @default.
• W2018861208 modified "2023-10-02" @default.
• W2018861208 title "Level of Sedation with Nitrous Oxide for Pediatric Medical Procedures" @default.
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• W2018861208 doi "https://doi.org/10.1213/ane.0b013e3181d539cf" @default.
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