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- W2018873507 abstract "Receptor binding specificity is an essential element in regulating the diverse activities of fibroblast growth factors (FGFs). FGF7 is ideal to study how this specificity is conferred at the structural level, as it interacts exclusively with one isoform of the FGF-receptor (FGFR) family, known as FGFR2IIIb. Previous mutational analysis suggested the importance of the beta4/beta5 loop of FGF7 in specific receptor recognition. Here a theoretical model of FGFR2IIIb/FGF7 complex showed that this loop interacts with the FGFR2IIIb unique exon. In addition, the model revealed new residues that either directly interact with the FGFR2IIIb unique exon (Asp63, Leu142) or facilitate this interaction (Arg65). Mutations in these residues reduced both receptor binding affinity and biological activity of FGF7. Altogether, these results provide the basis for understanding how receptor-binding specificity of FGF7 is conferred at the structural level." @default.
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- W2018873507 date "2003-08-27" @default.
- W2018873507 modified "2023-09-27" @default.
- W2018873507 title "Structure-based mutational analyses in FGF7 identify new residues involved in specific interaction with FGFR2IIIb" @default.
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- W2018873507 doi "https://doi.org/10.1016/s0014-5793(03)00909-8" @default.
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