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- W2018875185 abstract "Ibutilide is a ‘pure’ class III antiarrhythmic drug, used intravenously against atrial flutter and fibrillation. At a cellular level it exerts two main actions: induction of a persistent Na+ current sensitive to dihydropyridine Ca2+ channel blockers and potent inhibition of the cardiac rapid delayed rectifier K+ current, by binding within the channel pore cavity upon channel gating. Ibutilide has been shown to terminate atrial flutter and fibrillation in animal studies, with some risk of ventricular pro-arrhythmia. Experimental models of hypertrophy/heart failure show altered sensitivity to ibutilide, with increased dispersion of repolarisation and incidence of pro-arrhythmia. Patient trials show that ibutilide is effective at terminating atrial arrhythmias when given alone, and that it can increase effectiveness and reduce energy requirements of electrical cardioversion. The risk to patients of polymorphic ventricular tachycardia necessitates careful patient selection and monitoring during and after treatment. An ibutilide analogue, trecetilide, requires further investigation but may offer a less readily metabolised and pro-arrhythmic alternative to ibutilide." @default.
- W2018875185 created "2016-06-24" @default.
- W2018875185 creator A5037737415 @default.
- W2018875185 creator A5071085963 @default.
- W2018875185 date "2005-05-01" @default.
- W2018875185 modified "2023-10-18" @default.
- W2018875185 title "Ibutilide – recent molecular insights and accumulating evidence for use in atrial flutter and fibrillation" @default.
- W2018875185 cites W103658323 @default.
- W2018875185 cites W113683504 @default.
- W2018875185 cites W130141589 @default.
- W2018875185 cites W1534708542 @default.
- W2018875185 cites W153479715 @default.
- W2018875185 cites W1557874646 @default.
- W2018875185 cites W1767142556 @default.
- W2018875185 cites W1964127609 @default.
- W2018875185 cites W1965079936 @default.
- W2018875185 cites W1965514804 @default.
- W2018875185 cites W1966064887 @default.
- W2018875185 cites W1969839521 @default.
- W2018875185 cites W1982290844 @default.
- W2018875185 cites W1982944586 @default.
- W2018875185 cites W1985718987 @default.
- W2018875185 cites W1990589284 @default.
- W2018875185 cites W1991580513 @default.
- W2018875185 cites W1994711365 @default.
- W2018875185 cites W1995340775 @default.
- W2018875185 cites W1997206770 @default.
- W2018875185 cites W2002374666 @default.
- W2018875185 cites W2002967053 @default.
- W2018875185 cites W2006214313 @default.
- W2018875185 cites W2006639091 @default.
- W2018875185 cites W2008364262 @default.
- W2018875185 cites W2010476622 @default.
- W2018875185 cites W2013751224 @default.
- W2018875185 cites W2013863450 @default.
- W2018875185 cites W2014041843 @default.
- W2018875185 cites W2016718314 @default.
- W2018875185 cites W2021320779 @default.
- W2018875185 cites W2021818989 @default.
- W2018875185 cites W2022238342 @default.
- W2018875185 cites W2031027370 @default.
- W2018875185 cites W2038925265 @default.
- W2018875185 cites W2039230012 @default.
- W2018875185 cites W2040440511 @default.
- W2018875185 cites W2040511157 @default.
- W2018875185 cites W2041491202 @default.
- W2018875185 cites W2042078753 @default.
- W2018875185 cites W2044396808 @default.
- W2018875185 cites W2049925361 @default.
- W2018875185 cites W2052344496 @default.
- W2018875185 cites W2054188915 @default.
- W2018875185 cites W2054656310 @default.
- W2018875185 cites W2060841225 @default.
- W2018875185 cites W2062206620 @default.
- W2018875185 cites W2066805338 @default.
- W2018875185 cites W2069116952 @default.
- W2018875185 cites W2070350109 @default.
- W2018875185 cites W2078761712 @default.
- W2018875185 cites W2080344183 @default.
- W2018875185 cites W2081572258 @default.
- W2018875185 cites W2082616200 @default.
- W2018875185 cites W2086462421 @default.
- W2018875185 cites W2087447511 @default.
- W2018875185 cites W2094875484 @default.
- W2018875185 cites W2096338776 @default.
- W2018875185 cites W2096517541 @default.
- W2018875185 cites W2104011651 @default.
- W2018875185 cites W2106996297 @default.
- W2018875185 cites W2107763854 @default.
- W2018875185 cites W2108753291 @default.
- W2018875185 cites W2120263248 @default.
- W2018875185 cites W2121778527 @default.
- W2018875185 cites W2121804426 @default.
- W2018875185 cites W2124994088 @default.
- W2018875185 cites W2128780696 @default.
- W2018875185 cites W2129291556 @default.
- W2018875185 cites W2129393568 @default.
- W2018875185 cites W2130185573 @default.
- W2018875185 cites W2130780862 @default.
- W2018875185 cites W2132505348 @default.
- W2018875185 cites W2133279764 @default.
- W2018875185 cites W2137434301 @default.
- W2018875185 cites W2143518969 @default.
- W2018875185 cites W2151074096 @default.
- W2018875185 cites W2154892273 @default.
- W2018875185 cites W2163175442 @default.
- W2018875185 cites W2318887979 @default.
- W2018875185 cites W2319006749 @default.
- W2018875185 cites W2324359747 @default.
- W2018875185 cites W3023254611 @default.
- W2018875185 cites W316750 @default.
- W2018875185 cites W4252866508 @default.
- W2018875185 cites W4294882136 @default.
- W2018875185 doi "https://doi.org/10.1517/13543784.14.5.655" @default.
- W2018875185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15926871" @default.
- W2018875185 hasPublicationYear "2005" @default.
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