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- W2018882885 abstract "In rats destined to become obese as a result of lesion placement in the ventromedial hypothalamus, study of serial biopsy specimens of epidymal fat showed that impairment of epinephrine stimulated free fatty acid (FFA) release to incubation medium occurred more promptly than the alteration in distribution of total tissue (largely glyceride) fatty acids. Both were nearly fully developed by the sixth postoperative day, well before gross obesity was manifest. When the alteration of fatty acid distribution in tissue reached full development its extent became closely correlated with the reduction in hormone stimulated FFA release. The findings support the concept that in rats with hypothalamic lesions predisposing to obesity there is an early impairment of the hormone sensitive lipase system of adipose tissue, and that this defect underlies the alteration in the pattern of distribution of fatty acids within the tissue." @default.
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- W2018882885 title "Dynamics of development of the metabolic and compositional alterations of depot fat in hypothalamic obese rats" @default.
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- W2018882885 doi "https://doi.org/10.1016/0026-0495(66)90007-2" @default.
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