FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018891149> ?p ?o ?g. }

• W2018891149 abstract "Extracellular acidification is a hallmark of a number of debilitating pathologies including cancer, ischemia and inflammation. We have recently shown that in human granule precursor tumour cells a fall in extracellular pH triggers increases in intracellular Ca(2+) concentration through activation of G-protein coupled proton-sensing receptors coupling to phospholipase C. This pH-dependent rise in cytosolic Ca(2+) led to activation of the extracellular signal-regulated kinase ERK, providing a mechanistic explanation of how extracellular acidification can promote tumour growth. We now find that differentiation of granule precursor tumour cells profoundly affects their ability to respond to extracellular acidification with gene transcription. Differentiating cells have a lower Ca(2+) release probability from intracellular Ca(2+) stores upon acidification and cells that respond have a significantly smaller and slower Ca(2+) signal than proliferating cells. Importantly, Ca(2+) release in differentiating cells fails to evoke ERK phosphorylation. This altered responsiveness of differentiating cells is not due to reduced proton-sensing receptor expression or diminished Ca(2+) store content. Rather, our results suggest that in differentiating cells, the proton-sensing receptor couples less effectively to phospholipase C activation and IP(3) formation. Hence, the ability of human granule cells to respond to extracellular acidification by generating Ca(2+) signals and ERK activation is state-dependent, being lost upon differentiation." @default.
• W2018891149 created "2016-06-24" @default.
• W2018891149 creator A5013260016 @default.
• W2018891149 creator A5026204246 @default.
• W2018891149 creator A5040136914 @default.
• W2018891149 creator A5067128730 @default.
• W2018891149 date "2009-04-01" @default.
• W2018891149 modified "2023-09-25" @default.
• W2018891149 title "Differentiation impairs low pH-induced Ca2+ signaling and ERK phosphorylation in granule precursor tumour cells" @default.
• W2018891149 cites W1923918181 @default.
• W2018891149 cites W1964628210 @default.
• W2018891149 cites W1972666526 @default.
• W2018891149 cites W1982910988 @default.
• W2018891149 cites W1993016627 @default.
• W2018891149 cites W1997727989 @default.
• W2018891149 cites W2004234324 @default.
• W2018891149 cites W2004684765 @default.
• W2018891149 cites W2006549675 @default.
• W2018891149 cites W2008657049 @default.
• W2018891149 cites W2015674248 @default.
• W2018891149 cites W2016553429 @default.
• W2018891149 cites W2033936610 @default.
• W2018891149 cites W2045585709 @default.
• W2018891149 cites W2046257292 @default.
• W2018891149 cites W2060510699 @default.
• W2018891149 cites W2062608680 @default.
• W2018891149 cites W2064797517 @default.
• W2018891149 cites W2068789325 @default.
• W2018891149 cites W2073771554 @default.
• W2018891149 cites W2078803304 @default.
• W2018891149 cites W2082461969 @default.
• W2018891149 cites W2090875715 @default.
• W2018891149 cites W2127012396 @default.
• W2018891149 cites W2133411368 @default.
• W2018891149 cites W2155935601 @default.
• W2018891149 cites W2158496649 @default.
• W2018891149 cites W4233595534 @default.
• W2018891149 doi "https://doi.org/10.1016/j.ceca.2009.01.002" @default.
• W2018891149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19249096" @default.
• W2018891149 hasPublicationYear "2009" @default.
• W2018891149 type Work @default.
• W2018891149 sameAs 2018891149 @default.
• W2018891149 citedByCount "10" @default.
• W2018891149 countsByYear W20188911492013 @default.
• W2018891149 countsByYear W20188911492015 @default.
• W2018891149 countsByYear W20188911492016 @default.
• W2018891149 countsByYear W20188911492017 @default.
• W2018891149 countsByYear W20188911492019 @default.
• W2018891149 countsByYear W20188911492021 @default.
• W2018891149 crossrefType "journal-article" @default.
• W2018891149 hasAuthorship W2018891149A5013260016 @default.
• W2018891149 hasAuthorship W2018891149A5026204246 @default.
• W2018891149 hasAuthorship W2018891149A5040136914 @default.
• W2018891149 hasAuthorship W2018891149A5067128730 @default.
• W2018891149 hasConcept C11960822 @default.
• W2018891149 hasConcept C181199279 @default.
• W2018891149 hasConcept C184235292 @default.
• W2018891149 hasConcept C185592680 @default.
• W2018891149 hasConcept C2778597717 @default.
• W2018891149 hasConcept C28406088 @default.
• W2018891149 hasConcept C55493867 @default.
• W2018891149 hasConcept C57074206 @default.
• W2018891149 hasConcept C62478195 @default.
• W2018891149 hasConcept C79879829 @default.
• W2018891149 hasConcept C86803240 @default.
• W2018891149 hasConcept C95444343 @default.
• W2018891149 hasConcept C98539663 @default.
• W2018891149 hasConceptScore W2018891149C11960822 @default.
• W2018891149 hasConceptScore W2018891149C181199279 @default.
• W2018891149 hasConceptScore W2018891149C184235292 @default.
• W2018891149 hasConceptScore W2018891149C185592680 @default.
• W2018891149 hasConceptScore W2018891149C2778597717 @default.
• W2018891149 hasConceptScore W2018891149C28406088 @default.
• W2018891149 hasConceptScore W2018891149C55493867 @default.
• W2018891149 hasConceptScore W2018891149C57074206 @default.
• W2018891149 hasConceptScore W2018891149C62478195 @default.
• W2018891149 hasConceptScore W2018891149C79879829 @default.
• W2018891149 hasConceptScore W2018891149C86803240 @default.
• W2018891149 hasConceptScore W2018891149C95444343 @default.
• W2018891149 hasConceptScore W2018891149C98539663 @default.
• W2018891149 hasLocation W20188911491 @default.
• W2018891149 hasLocation W20188911492 @default.
• W2018891149 hasOpenAccess W2018891149 @default.
• W2018891149 hasPrimaryLocation W20188911491 @default.
• W2018891149 hasRelatedWork W1964028861 @default.
• W2018891149 hasRelatedWork W1978610119 @default.
• W2018891149 hasRelatedWork W1980263666 @default.
• W2018891149 hasRelatedWork W1981440002 @default.
• W2018891149 hasRelatedWork W1982910988 @default.
• W2018891149 hasRelatedWork W1984241186 @default.
• W2018891149 hasRelatedWork W1987008602 @default.
• W2018891149 hasRelatedWork W2003909363 @default.
• W2018891149 hasRelatedWork W2012598982 @default.
• W2018891149 hasRelatedWork W2024091110 @default.
• W2018891149 hasRelatedWork W2039628529 @default.
• W2018891149 hasRelatedWork W2052889275 @default.
• W2018891149 hasRelatedWork W2053080879 @default.
• W2018891149 hasRelatedWork W2060834758 @default.
• W2018891149 hasRelatedWork W2073771554 @default.
• W2018891149 hasRelatedWork W2074911197 @default.

• next