FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018895248> ?p ?o ?g. }

• W2018895248 endingPage "229" @default.
• W2018895248 startingPage "221" @default.
• W2018895248 abstract "Ras GTPases cycle between active GTP-bound and inactive GDP-bound forms to regulate a multitude of cellular processes, including cell growth, differentiation, and apoptosis. The activation state of Ras is regulated by protein modulatory agents that accelerate the slow intrinsic rates of GDP dissociation and GTP hydrolysis. Similar to the action of guanine-nucleotide exchange factors, the rate of GDP dissociation can be greatly enhanced by the reaction of Ras with small-molecule redox agents, such as nitrogen dioxide, which can promote Ras activation. Nitrogen dioxide is an autoxidation product of nitric oxide and can react with an accessible cysteine of Ras to cause oxidation of the bound guanine nucleotide to facilitate Ras guanine nucleotide dissociation. Glutathione has also been reported to modify Ras and alter its activity. To elucidate the mechanism by which glutathione alters Ras guanine nucleotide binding properties, we performed NMR, top-down and bottom-up mass spectrometry, and biochemical analyses of glutathiolated Ras. We determined that treatment of H-Ras, lacking the nonconserved hypervariable region, with oxidized glutathione results in glutathiolation specifically at cysteine 118. However, glutathiolation does not alter Ras structure or biochemical properties. Rather, changes in guanine nucleotide binding properties and Ras activity occur upon exposure of Ras to free radicals, presumably through the generation of a cysteine 118 thiyl radical. Interestingly, Ras glutathiolation protects Ras from further free radical-mediated activation events. Therefore, glutathiolation does not affect Ras activity unless Ras is modified by glutathione through a radical-mediated mechanism." @default.
• W2018895248 created "2016-06-24" @default.
• W2018895248 creator A5009563657 @default.
• W2018895248 creator A5016588335 @default.
• W2018895248 creator A5018067681 @default.
• W2018895248 creator A5065140987 @default.
• W2018895248 creator A5068312423 @default.
• W2018895248 date "2013-04-01" @default.
• W2018895248 modified "2023-09-30" @default.
• W2018895248 title "Glutathiolated Ras: Characterization and implications for Ras activation" @default.
• W2018895248 cites W1500411229 @default.
• W2018895248 cites W1512538844 @default.
• W2018895248 cites W154635582 @default.
• W2018895248 cites W1575277639 @default.
• W2018895248 cites W1580530266 @default.
• W2018895248 cites W1821918060 @default.
• W2018895248 cites W1952027208 @default.
• W2018895248 cites W1965688832 @default.
• W2018895248 cites W1968388033 @default.
• W2018895248 cites W1970203053 @default.
• W2018895248 cites W1972806200 @default.
• W2018895248 cites W1973317841 @default.
• W2018895248 cites W1975186819 @default.
• W2018895248 cites W1984680858 @default.
• W2018895248 cites W1992864103 @default.
• W2018895248 cites W1994150194 @default.
• W2018895248 cites W2000206488 @default.
• W2018895248 cites W2001093390 @default.
• W2018895248 cites W2001504395 @default.
• W2018895248 cites W2006659891 @default.
• W2018895248 cites W2010127951 @default.
• W2018895248 cites W2013807298 @default.
• W2018895248 cites W2018076136 @default.
• W2018895248 cites W2018542769 @default.
• W2018895248 cites W2025225219 @default.
• W2018895248 cites W2026771742 @default.
• W2018895248 cites W2029652412 @default.
• W2018895248 cites W2031193604 @default.
• W2018895248 cites W2032040152 @default.
• W2018895248 cites W2037574965 @default.
• W2018895248 cites W2043820536 @default.
• W2018895248 cites W2047627595 @default.
• W2018895248 cites W2050420714 @default.
• W2018895248 cites W2053379859 @default.
• W2018895248 cites W2053533924 @default.
• W2018895248 cites W2054913058 @default.
• W2018895248 cites W2056698109 @default.
• W2018895248 cites W2057193041 @default.
• W2018895248 cites W2059390568 @default.
• W2018895248 cites W2063650074 @default.
• W2018895248 cites W2064131920 @default.
• W2018895248 cites W2065524871 @default.
• W2018895248 cites W2075412225 @default.
• W2018895248 cites W2077180958 @default.
• W2018895248 cites W2078394930 @default.
• W2018895248 cites W2080206499 @default.
• W2018895248 cites W2086362820 @default.
• W2018895248 cites W2087541185 @default.
• W2018895248 cites W2090046344 @default.
• W2018895248 cites W2101327974 @default.
• W2018895248 cites W2105517156 @default.
• W2018895248 cites W2111778006 @default.
• W2018895248 cites W2162805603 @default.
• W2018895248 cites W2164558711 @default.
• W2018895248 cites W2169746759 @default.
• W2018895248 cites W2169821755 @default.
• W2018895248 cites W2173344695 @default.
• W2018895248 cites W4232777855 @default.
• W2018895248 doi "https://doi.org/10.1016/j.freeradbiomed.2012.10.531" @default.
• W2018895248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3985386" @default.
• W2018895248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23123410" @default.
• W2018895248 hasPublicationYear "2013" @default.
• W2018895248 type Work @default.
• W2018895248 sameAs 2018895248 @default.
• W2018895248 citedByCount "30" @default.
• W2018895248 countsByYear W20188952482013 @default.
• W2018895248 countsByYear W20188952482014 @default.
• W2018895248 countsByYear W20188952482015 @default.
• W2018895248 countsByYear W20188952482016 @default.
• W2018895248 countsByYear W20188952482017 @default.
• W2018895248 countsByYear W20188952482018 @default.
• W2018895248 countsByYear W20188952482019 @default.
• W2018895248 countsByYear W20188952482020 @default.
• W2018895248 countsByYear W20188952482021 @default.
• W2018895248 countsByYear W20188952482022 @default.
• W2018895248 countsByYear W20188952482023 @default.
• W2018895248 crossrefType "journal-article" @default.
• W2018895248 hasAuthorship W2018895248A5009563657 @default.
• W2018895248 hasAuthorship W2018895248A5016588335 @default.
• W2018895248 hasAuthorship W2018895248A5018067681 @default.
• W2018895248 hasAuthorship W2018895248A5065140987 @default.
• W2018895248 hasAuthorship W2018895248A5068312423 @default.
• W2018895248 hasBestOaLocation W20188952482 @default.
• W2018895248 hasConcept C104317684 @default.
• W2018895248 hasConcept C118716 @default.
• W2018895248 hasConcept C126619667 @default.
• W2018895248 hasConcept C181199279 @default.
• W2018895248 hasConcept C185592680 @default.

• next